Correlation of left atrial wall thickness and atrial remodeling in atrial fibrillation Study based on low-dose-ibutilide-facilitated catheter ablation
Correlation of left atrial wall thickness and atrial remodeling in atrial fibrillation Study based on low-dose-ibutilide-facilitated catheter ablation
复制标题
基于小剂量伊布利特导管消融的左心房壁厚度与心房重构的相关性研究
DOI：
10.1097/md.0000000000015170
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发表时间：
2019-04-01
期刊：
影响因子：
1.6
通讯作者：
Yang, Xinchun
中科院分区：
文献类型：
--
作者：
Zuo, Kun;Li, Kuibao;Yang, Xinchun
心房重构在心房颤动（AF）的发展过程中起着重要作用。左房壁厚度（LAT）是一个主观的和容易获得的指标，涉及结构重构。因此，我们的目的是研究LAT和心房重构底物之间的关系，并探讨LAT对强维持底物和导管消融反应差的预测作用。然后进行低剂量伊布利特辅助导管消融，根据对环肺静脉隔离或复杂碎裂心房电图消融的反应，将心房维持底物分为弱、轻度和强。在随访期间，评估成功率。LAT表现出从弱、轻度到强维持基质的进行性增厚趋势（屋顶：2.2mm vs. 2.6mm vs. 3.9mm，P
Atrial remodeling plays a significant role during the progression of atrial fibrillation (AF). Left atrial wall thickness (LAT) is a subjective and easily acquirable indicator referring to structural remodeling. Therefore, we aimed to investigate the association between LAT and atrial remodeling substrate, and to explore the predictive role of LAT about strong maintenance substrate and poor response to catheter ablation.LAT was measured by cardiac computed tomography in 2 selected locations (roof and floor) in 100 persistent AF patients. Then the low-dose-ibutilide-facilitated catheter ablation was performed and atrial maintenance substrate was categorized as weak, mild, and strong, based on the response to circumferential pulmonary vein isolation or complex fractionated atrial electrograms ablation. During follow-up, the success rate was evaluated. LAT showed a progressive thickening tendency from weak, mild, to strong maintenance substrate (roof: 2.2mm vs. 2.6mm vs. 3.9mm, P