Isotopic Control over Self-Assembly in Supramolecular Gels
Isotopic Control over Self-Assembly in Supramolecular Gels
复制标题
DOI：
10.1021/acs.langmuir.0c01552
复制
发表时间：
2020-07-28
期刊：
影响因子：
3.9
通讯作者：
Adams, Dave J.
中科院分区：
文献类型：
--
作者：
McAulay, Kate;Wang, Han;Adams, Dave J.
在研究基于多肽的系统时，通常会在H2O和D2O之间切换，假设这种变化不会产生任何影响。在这里，我们描述了在一些低分子质量的二肽凝胶中从H2O转变为D2O的效果。凝胶是通过降低pH值而形成的。在大多数情况下，在高pH值下形成的结构几乎没有区别，但这并不是普遍正确的。降低pH值会影响凝胶的动力学，在某些情况下，支撑凝胶网络结构的结构也会不同。在自组装结构中存在差异的地方，所产生的凝胶特性也不同。因此，我们证明了对凝胶性质的同位素控制是可能的。
It is common to switch between H2O and D2O when examining peptide-based systems, with the assumption being that there are no effects from this change. Here, we describe the effect of changing from H2O to D2O in a number of low-molecular-weight dipeptide-based gels. Gels are formed by decreasing the pH. In most cases, there is little difference in the structures formed at high pH, but this is not universally true. On lowering the pH, the kinetics of gelation are affected and, in some cases, the structures underpinning the gel network are different. Where there are differences in the self-assembled structures, the resulting gel properties are different. We, therefore, show that isotopic control over gel properties is possible.