Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.
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DOI：
10.3390/nu13010028
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发表时间：
2020-12-23
期刊：
影响因子：
5.9
通讯作者：
Sharma A
中科院分区：
文献类型：
--
作者：
Karunaratne TB;Okereke C;Seamon M;Purohit S;Wakade C;Sharma A
帕金森病（PD）的发病机制中涉及到许多研究的生态失调。测序技术和计算的进步导致了关于PD等疾病中病原性细菌谱的混杂数据。微生物组的变化，短链脂肪酸（SCFA）产生细菌的减少和内毒素产生细菌的增加可能有助于PD的发病机制。GPR109A是一种在肠上皮细胞和免疫细胞表面发现的G蛋白偶联受体，在控制肠通透性和炎症级联反应中起关键作用。GPR109A受体的缺乏与紧密连接蛋白浓度的降低相关，导致肠通透性增加和对炎症的易感性。在炎症状态下，丁酸盐通过GPR109A起作用，以增加紧密连接蛋白的浓度并改善肠道通透性。多巴胺能药物可加重PD患者的烟酸缺乏症。烟酸补充剂已显示将巨噬细胞极化从促炎性转变为抗炎性。烟酸和丁酸是G蛋白偶联受体GPR109A的重要配体，具有广阔的应用前景。
Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal epithelium and immune cells, plays a key role in controlling intestinal permeability and the inflammatory cascade. The absence of GPR109A receptors is associated with decreased concentration of tight junction proteins, leading to increased intestinal permeability and susceptibility to inflammation. In inflammatory states, butyrate acts via GPR109A to increase concentrations of tight junction proteins and improve intestinal permeability. Niacin deficiency is exacerbated in PD by dopaminergic medications. Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.
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影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
DOI：
10.1042/cs0560089
发表时间：
1979-01-01
期刊：
CLINICAL SCIENCE AND MOLECULAR MEDICINE
影响因子：
--
作者：
BENDER, DA;EARL, CJ;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
4.3
作者：
Fava, Francesca;Danese, Silvio
通讯作者：
Danese, Silvio
影响因子：
1.1
作者：
Garrido-Maraver, Juan;Cordero, Mario D.;Sanchez-Alcazar, Jose A.
通讯作者：
Sanchez-Alcazar, Jose A.
丁酸钠以 GPR109A 依赖性方式减轻断奶仔猪腹泻并促进结肠中紧密连接蛋白的表达
影响因子：
--
作者：
Feng, Wenqian;Wu, Yancheng;Liu, Juxiong
通讯作者：
Liu, Juxiong