Small Gray Matter Volume in Orbitofrontal Cortex in Prader-Willi Syndrome: A Voxel-Based MRI Study
Small Gray Matter Volume in Orbitofrontal Cortex in Prader-Willi Syndrome: A Voxel-Based MRI Study
复制标题
DOI：
10.1002/hbm.21089
复制
发表时间：
2011-07-01
影响因子：
4.8
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Ogura, Kaeko;Fujii, Toshikatsu;Mori, Etsuro
Prader-Willi综合征（PWS）是一种遗传决定的神经发育障碍，表现为行为症状，包括食欲过盛、抑制解除和强迫行为。PWS患者的行为问题与额叶病变患者的行为问题惊人地相似，特别是那些影响眶额皮质（OFC）的患者。然而，额叶神经解剖异常尚未建立在PWS。本研究的目的是寻找，使用体积分析，在额叶的形态变化，特别是眶额皮层，与PWS的个人的大脑。12名患有PWS的成年人和13名年龄和性别匹配的对照受试者参加了结构磁共振成像（MRI）扫描。将全脑图像分割并归一化到标准立体定向空间。使用基于体素的形态测量法比较PWS组和对照组之间的区域灰质体积。PWS受试者在几个区域显示出小的灰质体积，包括OFC、尾状核、颞下回、中央前回、辅助运动区、中央后回和小脑。在一项单独的分析中，OFC中的小灰质体积仍然显着，其中包括总灰质体积作为协变量。这些初步研究结果表明，PWS患者的神经行为症状与这些区域的脑结构异常有关。《脑地图》32：1059-1066，2011年。(C)2010 Wiley-Liss，Inc.
Prader-Willi syndrome (PWS) is a genetically determined neurodevelopmental disorder presenting with behavioral symptoms including hyperphagia, disinhibition, and compulsive behavior. The behavioral problems in individuals with PWS are strikingly similar to those in patients with frontal pathologies, particularly those affecting the orbitofrontal cortex (OFC). However, neuroanatomical abnormalities in the frontal lobe have not been established in PWS. The aim of this study was to look, using volumetric analysis, for morphological changes in the frontal lobe, especially the OFC, of the brains of individuals with PWS. Twelve adults with PWS and 13 age-and gender-matched control subjects participated in structural magnetic resonance imaging (MRI) scans. The whole-brain images were segmented and normalized to a standard stereotactic space. Regional gray matter volumes were compared between the PWS group and the control group using voxel-based morphometry. The PWS subjects showed small gray-matter volume in several regions, including the OFC, caudate nucleus, inferior temporal gyrus, precentral gyrus, supplementary motor area, postcentral gyrus, and cerebellum. The small gray-matter volume in the OFC remained significant in a separate analysis that included total gray matter volume as a covariate. These preliminary findings suggest that the neurobehavioral symptoms in individuals with PWS are related to structural brain abnormalities in these areas. Hum Brain Mapp 32: 1059-1066, 2011. (C) 2010 Wiley-Liss, Inc.