[Suggestions from a centenarian study--aging and inflammation].
[Suggestions from a centenarian study--aging and inflammation].
复制标题
[来自百岁老人研究的建议——衰老与炎症]。
DOI：
10.3143/geriatrics.38.121
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
K. Shimizu
中科院分区：
文献类型：
--
作者：
N. Hirose;Y. Arai;K. Yamamura;S. Nakazawa;M. Takayama;Y. Ebihara;S. Homma;K. Shimizu
随着老年人数量的迅速增加，老年人保持自主性对个人和社会都很重要。为了了解如何实现成功的老龄化，我们调查了百岁老人的状况。东京百岁老人的特征是1）营养参数水平低，2）胆固醇和HDL-胆固醇水平低，3）红细胞和血红蛋白水平低，4）CRP水平高，5）同型半胱氨酸水平高，6）von Willbrand因子水平高。痴呆的发病率为59.3%。这些特征是由于老化本身还是其他因素造成的？我们研究了营养状况、炎症和同型半胱氨酸水平对这些特征的影响。白蛋白水平与血脂、红细胞、日常生活活动能力及认知功能有关。CRP水平与白蛋白水平相关，提示炎症与营养状况有关。同型半胱氨酸水平与血管性血友病因子水平相关，提示同型半胱氨酸与内皮损伤有关。从这些数据中，我们提出了这样的假设，即促炎状态与衰老有关，导致了百岁老人的部分特征。同型半胱氨酸是内皮损伤的部分原因。干预抑制炎症状态和同型半胱氨酸水平可能会提高高龄老人的生活质量。
With the numbers of elderly increasing rapidly, it is important for both individuals and society that the oldest old maintains autonomy. To know how to attain successful aging, we investigate the status of centenarians. The characteristics of centenarians in Tokyo is 1) low level of nutritional parameters, 2) low level of cholesterol and HDL-cholesterol, 3) low level of red blood cells and hemoglobin, 4) high level of CRP, 5) high level of homocysteine, 6) high level of von Willbrand factor. The incidence of dementia is 59.3%. Are these characteristics due to aging itself or other factors? We examined the effect of nutritional status, inflammation and level of homocysteine on the characteristics. The level of albumin is associated with serum level of lipid, RBC, ADL and cognitive function. The level of CRP is related to the level of albumin, suggesting that inflammation is related to nutritional status. The level of homocysteine is associated with the level of von Willbrand factor, suggesting that homocysteine is related to endothelial injury. From these data, we propose the hypothesis that proinflammatory status is associated with aging, resulting in a part of characteristics of centenarians. Homocysteine is partly responsible for endothelial injury. Intervention to suppress proinflammatory status and homocysteine level may promote QOL in the oldest old.