The metabolic life and times of a T-cell.
The metabolic life and times of a T-cell.
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DOI：
10.1111/j.1600-065x.2010.00911.x
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发表时间：
2010-07
影响因子：
8.7
通讯作者：
Rathmell JC
中科院分区：
文献类型：
--
作者：
Michalek RD;Rathmell JC
淋巴细胞稳态的调节对于生产性免疫应答的发展和形成至关重要。必须维持细胞数量，以允许足够数量的淋巴细胞对抗外来病原体，但防止过量淋巴细胞的积累，这可能增加发生自身免疫或肿瘤的风险。细胞外源性生长因子对于维持体内平衡和细胞存活是必不可少的，并且越来越明显的是，这种控制的关键机制是通过调节细胞代谢。T细胞的代谢状态可以对细胞生长和存活甚至分化具有深远的影响。特别是，静息T细胞利用能量有效的氧化代谢，但当受到病原体的刺激而生长和增殖时，其转变为高度糖酵解代谢。抗原清除后，T细胞必须恢复到更静止的氧化代谢，以支持T细胞记忆。这篇综述强调了这些代谢变化如何与T细胞的生长和死亡在体内平衡和免疫的控制中错综复杂地联系在一起。
The regulation of lymphocyte homeostasis is critical for the development and formation of productive immune responses. Cell numbers must be maintained to allow sufficient numbers of lymphocytes to combat foreign pathogens but prevent the accumulation of excess lymphocytes that may increase the risk of developing autoimmunity or neoplasia. Cell extrinsic growth factors are essential to maintain homeostasis and cell survival, and it has become increasingly apparent that a key mechanism of this control is through regulation of cell metabolism. The metabolic state of T cells can have profound influences on cell growth and survival and even differentiation. In particular, resting T cells utilize an energy efficient oxidative metabolism but shift to a highly glycolytic metabolism when stimulated to grow and proliferate by pathogen encounter. After antigen clearance, T cells must return to a more quiescent oxidative metabolism to support T-cell memory. This review highlights how these metabolic changes may be intricately involved with both T-cell growth and death in the control of homeostasis and immunity.