The chromosome hypothesis of linkage applied to cases in sweet peas and primula
The chromosome hypothesis of linkage applied to cases in sweet peas and primula
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DOI：
10.1086/279428
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发表时间：
1914-01-01
影响因子：
2.9
通讯作者：
Bridges, CB
中科院分区：
文献类型：
--
作者：
Bridges, CB
关于联系的本质有两种观点。贝特森和他的同事提出的早期观点是，这种现象是生殖道中对称重复的表现。摩根和他的同事提出了一种更新的观点，根据染色体中基因的线性排列以及这些基因在正常配子发生过程中的历史来处理连锁。重复观点的倡导者很少将他们的原则应用于果蝇的结果，因为果蝇的结果因性别连锁而变得复杂。这种性别联系只是一个附加的，但是。完全独立的现象已被果蝇中的许多案例所证明，其中不涉及性别连锁，但其中基因彼此之间的连锁与性别连锁基因彼此之间的连锁属于同一类型。在本文中，我将试图表明，我们已成功应用于果蝇所有病例的连锁理论，无论涉及性连锁基因还是不显示性连锁的基因，同样适用于甜豌豆和报春花中发生的非性连锁病例。这种应用程序的唯一严重缺点在于为这些案例收集的数据的性质。用于确定连锁值的最不令人满意的数据形式是 F2 结果所呈现的数据。在两个隐性从相反父母进入的情况下（“排斥”），F2中的双隐性类别过小导致任何计算主题。到极大的错误。耦合的 F2 结果稍好一些，
THERE are two views as to the nature of linkage. The earlier view, developed by Ba~ teson and his co-workers, is that this phenomenon is an expression of symmetrical reduplications in the germ tract. A more recent view, developed by Morgan and his co-workers, treats linkage on the basis of a linear arrangement of genes in the chromosomes and of the history of these genes during normal ga-metogenesis. The advocates of the reduplication view have rarely applied their principles to the results on Drosophila on the ground that the results for Drosophila are complicated by sex-linkage. That sexlinkage is simply an additional, but. wholly independent, phenomenon, is proven by the many cases in Drosophilain which sex-linkage is not involved, yet in which the linlkage of the genes to each other is of the same'type as the linkage of sex-linked genes to each other. In this paper I shall attempt to show that the theory of linkage which we have successfully applied to all cases in Dr-osophila., whether involving sex-linked genes or genes which show no sex-linkage, applies equally well to the non-sex-linked cases occurring in sweet peas and primiula. The only serious drawback to such an application lies in the nature of the data which have been collected for these cases. The least satisfactory formal of data from which to determine a, linkage value is that presented by F2 results. In cases in which two recessives enter from opposite parents (" repulsion"), the excessive smallness of the double recessive class in F2 renders any calculation subject. to great error. Slightly better are the F2 results from coupling,