Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats
Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats
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DOI：
10.1006/nlme.1998.3895
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发表时间：
1999-11-01
影响因子：
2.7
通讯作者：
Di Scala, G
中科院分区：
文献类型：
--
作者：
Coutureau, E;Galani, R;Di Scala, G
潜在抑制（LI）是由于在与非条件刺激配对之前重复非强化预先暴露于条件刺激而导致的条件不足。累积数据表明，海马结构的大损伤会破坏 LI。然而，海马结构不同组成部分的选择性损伤的影响从未在同一研究和调节范式中直接得到解决。本研究的第一个实验旨在研究海马、下托或内嗅皮质的兴奋性毒性损伤在“偏离基线”条件情绪反应过程中对 LI 的影响。海马或下托损伤对 LI 或条件反射没有影响。相比之下，内嗅皮层损伤会破坏 LI，但不会改变条件反射。在实验 2 中，评估了相同大鼠在新环境中的运动活动。海马体的损伤增加了运动活动，而下托或内嗅皮层的损伤则没有效果。尽管 LI 和对新环境线索的习惯被认为涉及海马结构和中边缘通路之间的相互作用，但这些结果表明海马和内嗅皮层之间存在功能分离。 (C) 1999 年学术出版社。
Latent inhibition (LI) is the deficit of conditioning resulting from repeated nonreinforced preexposure to a conditioned stimulus before its pairing with an unconditioned stimulus. There are cumulative data showing that large lesions of the hippocampal formation disrupt LI. However, the effects of selective lesions of the different components of the hippocampal formation have never been directly addressed in the same study and conditioning paradigm. The first experiment of the present study aimed at investigating the effects of excitotoxic lesions of the hippocampus, subiculum, or entorhinal cortex on LI in an "off-baseline"-conditioned emotional response procedure. Hippocampus or subiculum lesions had no effect on either LI or conditioning. In contrast, entorhinal cortex lesions disrupted LI without modifying conditioning. In Experiment 2, locomotor activity in a novel environment was assessed in the same rats. Whereas lesions of hippocampus increased locomotor activity, lesions of the subiculum or the entorhinal cortex were devoid of effect. Although both LI and habituation to novel environmental cues are thought to involve interactions between the hippocampal formation and the mesolimbic pathway, these results indicate a functional dissociation between the hippocampus and the entorhinal cortex. (C) 1999 Academic Press.