The potential use of Chinese herbal medicines in treating allergic asthma
The potential use of Chinese herbal medicines in treating allergic asthma
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DOI：
10.1016/s1081-1206(10)61485-8
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发表时间：
2004-08-01
影响因子：
5.9
通讯作者：
Schofield, B
中科院分区：
文献类型：
--
作者：
Li, XM;Zhang, TF;Schofield, B
目的：从中药配方MSSM-002对过敏性哮喘小鼠模型的影响、体外对T(H)2细胞的免疫调节作用以及中药配方质量控制的标准化方法等方面探讨中药配方MSSM-002在哮喘治疗中的潜在应用。资料来源：2002年在德克萨斯州圣安东尼奥举行的美国过敏、哮喘和免疫学(ACAAI)补充替代医学年度科学会议上发表的信息。资料选择：所有讨论MSSM-002的ACAAI会议的报告均纳入本综述。结果：中药配方MSSM-002抑制了过敏性哮喘小鼠的气道高反应性和嗜酸性炎症。这些效应与地塞米松相当，但不伴随地塞米松对T(H)1反应的抑制。体外研究表明，MSSM-002可显著降低T(H)2极化小鼠脾细胞和人T(H)2细胞株抗原性诱导的TH2细胞因子的分泌，与地塞米松相比，MSSM-002不会引起细胞凋亡，也不具有细胞毒性，但与GATA-3的表达降低有关。结论：MSSM-002对过敏性哮喘具有治疗作用，对已建立的T(H)2细胞具有免疫调节作用，可能对哮喘患者有潜在的临床应用价值。
Objective: To discuss the potential use of the Chinese herbal formula MSSM-002 in treating asthma based on its effects on a murine model of allergic asthma, immunoregulatory actions on T(H)2 cells in vitro, and the means of standardization for herbal formula quality control.Data Sources: Information presented at the 2002 American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting International Symposium on Complementary Alternative Medicine in San Antonio, TX.Study Selection: All presentations from the ACAAI meeting that discussed MSSM-002 were considered for this review.Results: The Chinese herbal formula MSSM-002 suppressed airway hyperreactivity and eosinophilic inflammation in a murine model of allergic asthma. These effects were comparable to dexamethasone but were not accompanied by the suppression of T(H)1 responses seen with dexamethasone. In vitro studies demonstrated that MSSM-002 significantly decreased antigeninduced TH2 cytokine secretion by murine T(H)2 polarized splenocytes and human mucosal T(H)2 cell lines, which in contrast to dexamethasone did not cause apoptosis and was not cytotoxic but was associated with decreased GATA-3 expression. Chromatographic fingerprints of MSSM-002 and evaluation of in vivo actions showed that the quality of several batches of MSSM-002 was consistent.Conclusion: MSSM-002 has a therapeutic effect on allergic asthma and immunoregulatory actions on established T(H)2 cells and may prove to be of potential clinical benefit to asthma patients.