Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression
Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression
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DOI：
10.1017/s1461145709990721
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发表时间：
2010-06-01
影响因子：
4.8
通讯作者：
Wegener, Gregers
中科院分区：
文献类型：
--
作者：
Elfving, Betina;Plougmann, Pia Hogh;Wegener, Gregers
越来越多的证据表明，脑源性神经营养因子（BDNF）在抑郁症的病理生理中起着至关重要的作用。据报道，重度抑郁症患者血清中BDNF水平下降，并发现BDNF减少与疾病严重程度之间存在相关性。此外，在死后海马组织中，与未经治疗的受试者相比，接受抗抑郁药物治疗的受试者BDNF免疫反应性水平升高。这些发现表明抑郁症期间大脑和血清BDNF水平的平行变化。在几种动物模型中，BDNF在选定的大脑区域进行了测量。在抑郁症遗传大鼠模型Hinders Sensitive Line （FSL）和Flinders Resistant Line （FRL）大鼠的研究中，BDNF在前额皮质和海马（被认为是抑郁症的核心脑区）的水平没有差异。然而，据我们所知，大脑和血清BDNF水平从未在任何精神疾病模型中平行报道过。因此，我们检测了雄性FSL和FRL大鼠全血、血清、脑脊液（CSF）、海马和额叶皮质中BDNF的水平。与FRL大鼠相比，FSL大鼠血清和全血BDNF水平显著升高。相比之下，与FRL大鼠相比，FSL大鼠海马中BDNF水平显著降低，而额叶皮质和脑脊液中未发现差异。FSL/FRL大鼠海马、血清和全血中BDNF水平的差异调节进一步证实了神经营养因子与抑郁症病理生理有关的假设。
There is accumulating evidence that brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression. Decreased serum levels have been reported in major depression, and a correlation between BDNF reduction and the severity of the disease was found. Moreover, in post-mortem hippocampal tissue, increased levels of BDNF immunoreactivity have been reported in subjects treated with antidepressants compared to untreated subjects. These findings indicate parallel changes in brain and serum BDNF levels during depression. BDNF has been measured in selected brain areas in several animal models. In investigations between Hinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats, a genetic rat model of depression, no differences were found in BDNF levels in the frontal cortex and hippocampus, areas believed to be core brain regions in depression. However, to our knowledge brain and serum BDNF levels have never been reported in parallel for any psychiatric disease model. Therefore, we examined the levels of BDNF in whole blood, serum, cerebrospinal fluid (CSF), hippocampus, and frontal cortex in male FSL and FRL rats. BDNF levels in serum and whole blood of FSL rats were significantly increased compared to FRL rats. In contrast, in the hippocampus the BDNF level was significantly decreased in FSL compared to FRL rats while no differences were found in the frontal cortex and CSF. The differential regulation of the BDNF levels in hippocampus, serum, and whole blood hi FSL/FRL rats adds to the hypothesis that neurotrophic factors are related to the pathophysiology of depression.