Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer.
Mechanistic basis and clinical relevance of the role of transforming growth factor-β in cancer.
复制标题
转化生长因子-β在癌症中作用的机制基础和临床相关性
DOI：
10.7497/j.issn.2095-3941.2015.0015
复制
发表时间：
2015-12
影响因子：
5.5
通讯作者：
Zhao LJ
中科院分区：
文献类型：
--
作者：
Lin RL;Zhao LJ
转化生长因子-β（TGF-β）是癌症发生和发展的关键因子。TGF-β可以通过抑制细胞周期进程和在癌症进展的早期阶段刺激细胞凋亡来抑制肿瘤发生。然而，TGF-β可以调节癌症相关的过程，如细胞侵袭、远处转移和微环境改变，这些过程可以被癌细胞用于其在晚期阶段的优势。其机制包括促进血管生成、抑制抗肿瘤免疫和诱导上皮细胞向间质细胞转化。TGF-β表达与癌症预后之间的相关性也已被广泛研究。结果表明，TGF-β通路可以靶向治疗癌症;因此，在临床试验中研究了这种治疗的可行性。
Transforming growth factor-β (TGF-β) is a key factor in cancer development and progression. TGF-β can suppress tumorigenesis by inhibiting cell cycle progression and stimulating apoptosis in early stages of cancer progression. However, TGF-β can modulate cancer-related processes, such as cell invasion, distant metastasis, and microenvironment modification that may be used by cancer cells to their advantage in late stages. Corresponding mechanisms include angiogenesis promotion, anti-tumor immunity suppression, and epithelial-to-mesenchymal transition (EMT) induction. The correlation between TGF-β expression and cancer prognosis has also been extensively investigated. Results suggest that TGF-β pathway can be targeted to treat cancer; as such, the feasibility of this treatment is investigated in clinical trials.