Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma.
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DOI：
10.1038/bjc.1996.374
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发表时间：
1996-08
影响因子：
8.8
通讯作者：
Verspaget HW
中科院分区：
文献类型：
--
作者：
Sier CF;Kubben FJ;Ganesh S;Heerding MM;Griffioen G;Hanemaaijer R;van Krieken JH;Lamers CB;Verspaget HW
蛋白酶参与肿瘤的侵袭和转移。几种基质金属蛋白酶（MMPs）已被证明在各种人类癌症中增加。采用定量明胶酶谱法检测了50例胃癌及相应胃粘膜组织中MMP-2（明胶酶A）和MMP-9（明胶酶B）的水平。两种MMP水平在胃癌中均显著高于癌旁粘膜组织，相关性相对较差，与组织病理学分类（根据Laurén，WHO和TNM）无关。考克斯的多变量比例风险分析显示，高癌性MMP值对患者的不良总生存具有预后意义，与主要临床病理参数无关。
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Laurén, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters.