SERUM BILIRUBIN - PROGNOSTIC FACTOR IN PRIMARY BILIARY-CIRRHOSIS
SERUM BILIRUBIN - PROGNOSTIC FACTOR IN PRIMARY BILIARY-CIRRHOSIS
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DOI：
10.1136/gut.20.2.137
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发表时间：
1979-01-01
期刊：
影响因子：
24.5
通讯作者：
SCHAFFNER, F
中科院分区：
文献类型：
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作者：
SHAPIRO, JM;SMITH, H;SCHAFFNER, F
经证实的原发性胆汁性肝硬化患者[55]被随访数年或直至死亡。为每个患者构建的血清胆红素水平与时间的关系图显示了可变长度的初始稳定期，其中血清胆红素水平保持恒定。随后是一段时间的血清胆红素快速上升，最终导致患者死亡。每当连续2次血清胆红素值6个月。除了超过34 μ mol/l（2.0mg/dl），患者已进入疾病晚期，平均存活40个月。生存时间的置信限[95%]为32-74个月。如果连续2个月，胆红素值超过102 μ mol/l（6.0mg/dl），计算的存活时间为25个月。如果连续2个月，胆红素值超过170 μ mol/l（10.0 mg/dl），存活时间为17个月。在41名存活患者中，15名具有2个连续的血清胆红素水平> 34 μ mol/l（2.0 mg/dl）。与死亡患者中的42 μ mol/l/年（2.5mg/dl/年）相比，存活患者中胆红素上升的斜率仅为25 μ mol/l/年（1.5mg/dl/年）。患有这种疾病的患者现在可能会活得更长。
Patients [55] with proven primary biliary cirrhosis were followed for several yr or until death. A graph of the level of serum bilirubin vs. time that was constructed for each patient shows an initial stable period of variable length in which the serum bilirubin level remained constant. This was followed by a period of rapid rise in serum bilirubin which culminated in the patient''s death. Whenever 2 successive serum bilirubin values taken 6 mo. apart exceeded 34 .mu.mol/l (2.0 mg/dl) the patient had entered a late phase of disease and lived an average of 40 mo. Confidence limits [95%] on survival time were 32-74 mo. If 2 successive 6 mo. bilirubin values exceeded 102 .mu.mol/l (6.0 mg/dl), calculated survival time was 25 mo. and if 2 successive 6 mo. bilirubin values exceeded 170 .mu.mol/l (10.0 mg/dl), survival time was 17 mo. Of the 41 living patients, 15 had 2 consecutive serum bilirubin levels > 34 .mu.mol/l (2.0 mg/dl). The slope of the rising bilirubin in the living patients is only 25 .mu.mol/l per yr (1.5 mg/dl per yr) compared with 42 .mu.mol/l per yr (2.5 mg/dl per yr) in the dead patients. Patients with this disease now may be living considerably longer.