Circadian coupling between pancreatic secretion and intestinal motility in humans
Circadian coupling between pancreatic secretion and intestinal motility in humans
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DOI：
10.1152/ajpgi.2001.280.2.g273
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发表时间：
2001-02-01
影响因子：
4.5
通讯作者：
Layer, P
中科院分区：
文献类型：
--
作者：
Keller, J;Gröger, G;Layer, P
人类消化间期肠蠕动遵循昼夜节律，夜间活动减少，但昼夜胰腺外分泌尚不清楚。为了确定是否发生消化间期胰腺分泌的昼夜节律变化，并与运动事件，胰腺酶输出，近端空肠运动，和血浆胰多肽浓度进行了测量，在连续的白天和夜间期间（12小时）在7名健康志愿者使用口腔空肠多腔插管。研究在早晨或晚上随机开始。夜间运动减少（运动静止：67 +/- 22 vs. 146 +/- 37 min;运动指数：3.59 +/- 0.33 vs. 2.78 +/- 0.40 mmHg/min;均P < 0.05），但淀粉酶输出增加（273 +/- 78 vs. 384 +/- 100 U/min; P < 0.05），蛋白酶输出保持不变（P > 0.05）;因此，酶/运动比增加。淀粉酶产量在第一阶段总是最低的。运动而不是胰腺的昼夜节律活动与睡眠有关。胰多肽血浆浓度不变。因此，肠运动和胰腺外分泌功能可能具有不同的昼夜节律，即，夜间运动减少，分泌活动稳定。然而，消化间期运动和分泌活动的各个阶段之间的关联被保留。夜间酶/运动比的增加可能不是由胆碱能张力增加引起的。
Human interdigestive intestinal motility follows a circadian rhythm with reduced nocturnal activity, but circadian pancreatic exocrine secretion is unknown. To determine whether circadian changes in interdigestive pancreatic secretion occur and are associated with motor events, pancreatic enzyme outputs, proximal jejunal motility, and plasma pancreatic polypeptide concentrations were measured during consecutive daytime and nighttime periods (12 h each) in seven healthy volunteers using orojejunal multilumen intubation. Studies were randomly started in the morning or evening. Nocturnally, motility decreased (motor quiescence: 67 +/- 22 vs. 146 +/- 37 min; motility index: 3.59 +/- 0.33 vs. 2.78 +/- 0.40 mmHg/min; both P < 0.05) but amylase output increased (273 +/- 78 vs. 384 +/- 100 U/min; P < 0.05) and protease output remained unchanged (P > 0.05); consequently, enzyme/motility ratio increased. Amylase outputs were always lowest during phase I. Motor but not pancreatic circadian activities were associated with sleep. Pancreatic polypeptide plasma concentrations were unchanged. Consequently, intestinal motor and pancreatic exocrine functions may have different circadian rhythms, i.e., decreased motor and stable secretory activity during the night. However, the association between individual phases of interdigestive motor and secretory activity is preserved. The nocturnal increase in enzyme/motility ratio is probably not caused by increased cholinergic tone.