The combined effects of light and acute ischemia on the structure of the rabbit retina: a light and electron microscopic study.
The combined effects of light and acute ischemia on the structure of the rabbit retina: a light and electron microscopic study.
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光和急性缺血对兔视网膜结构的综合影响：光和电子显微镜研究。
DOI：
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发表时间：
1982
影响因子：
4.4
通讯作者：
W. Foulds
中科院分区：
文献类型：
--
作者：
N. Mckechnie;N. Johnson;W. Foulds
我们对家兔视网膜的超微结构进行了研究，以确定光和缺血的联合作用。将16只成年荷兰兔的两只眼睛暴露在接近或低于视网膜超微结构变化阈值的光线下。此外，每只动物的一只眼睛遭受四期压力诱导的全急性缺血中的一期。单独暴露于光下只会对受体细胞外节产生轻微的干扰。视网膜其余部分形态外观正常。暴露于光照射和缺血的联合损伤对内外视网膜产生了更大的损伤。光照和短时间缺血（15 ~ 30分钟）导致色素上皮水肿和受体细胞内外段紊乱。光照加上较长的缺血时间（45 ~ 60分钟）导致色素上皮结构严重紊乱，受体细胞外段破裂，内段线粒体破裂，神经视网膜严重水肿。讨论了光和缺血的这种成瘾或协同作用的含义。
The ultrastructure of the rabbit retina has been investigated to determine the combined effects of light and ischemia. Both eyes of 16 adult Dutch rabbits were exposed to light of an intensity known to be near or below the threshold for ultrastructural changes in the retina. In addition, one eye of each animal was subjected to one of four periods of pressure-induced total acute ischemia. Exposure to light alone resulted in only minor disturbances of the receptor cell outer segments. The remainder of the retina was of normal morphologic appearance. Exposure to the combined insults of light exposure and ischemia produced considerably more damage to the inner and outer retina. Light exposure combined with short periods of ischemia (15 to 30 min) resulted in edema of the pigment epithelium and disturbances of the receptor cell inner and outer segments. Light exposure combined with longer ischemic periods (45 to 60 min) resulted in severe disturbances in the structure of the pigment epithelium, breakdown of the receptor cell outer segments, rupture of the inner segment mitochondria, and severe edema of the neural retina. The implication of this addictive or synergistic action of light and ischemia is discussed.