Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene.
Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene.
复制标题
人谷氨酸-L-半胱氨酸连接酶催化 (GLCLC) 亚基基因的结构。
DOI：
10.1159/000015505
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Mulcahy,RT
中科院分区：
文献类型：
--
作者：
Gipp,JJ;Mulcahy,RT
谷氨酸-L-半胱氨酸连接酶（GLCL [EC 6.3. 2.2]，也称为γ-谷氨酰半胱氨酸合成酶）催化重要的细胞抗氧化剂谷胱甘肽合成中的限速反应。GLCL是由催化亚基（GLCLC）和调节亚基（GLCL）组成的异源二聚体。人GLCLC亚基基因（GLCLC）位于染色体6p 12，全长51.4kb，由16个外显子和15个内含子组成。
Glutamate-L-cysteine ligase (GLCL [EC 6.3. 2.2], also referred to as γ-glutamylcysteine synthetase) catalyzes the rate-limiting reaction in the synthesis of the important cellular antioxidant glutathione. GLCL is a heterodimer consisting of a catalytic (GLCLC) and a regulatory (GLCLR) subunit. The structure of the human GLCLC subunit gene, GLCLC, which has been mapped to chromosome 6p12, spans 51.4 kb and consists of 16 exons separated by 15 introns.