Effects of isolation rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats
Effects of isolation rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats
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DOI：
10.1007/s002130050705
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发表时间：
1998-10-01
影响因子：
3.4
通讯作者：
Linnoila, M
中科院分区：
文献类型：
--
作者：
Hall, FS;Huang, S;Linnoila, M
自愿乙醇（EtOH）的消费量增加隔离饲养在几个大鼠品系。以下实验检查了与Wistar大鼠相比，隔离饲养对Fawn Hooded大鼠（一种偏好酒精的大鼠品系）的基础行为和酒精刺激行为的影响。在这两种情况下检查运动活动和焦虑。基础运动活动是较高的两个菌株在低光条件下，但在明亮的光线条件下，隔离受试者：这种差异只在Wistar大鼠中观察到。仅在隔离饲养的大鼠中观察到EtOH的运动刺激作用。在高架十字迷宫中，Fawn Hooded大鼠在弱光条件下比Wistar大鼠更焦虑，但在强光条件下，Wistar socials比所有其他组都更少焦虑。在明亮的光照条件下，在高架十字迷宫中，1.5 mg/kg EtOH给药对Fawn Hooded大鼠产生抗焦虑反应，但对Wistar大鼠（尤其是Wistar分离株）的影响较小。总之，虽然应变和隔离饲养运动和焦虑的影响，以及乙醇的刺激和抗焦虑作用，这些影响似乎是独立的。
Voluntary ethanol (EtOH) consumption is increased by isolation-rearing in several rat strains. The following experiments examined the effects of isolation-rearing on basal and ethanol-stimulated behavior in Fawn Hooded rats, an alcohol-preferring rat strain, compared to Wistar rats. Locomotor activity and anxiety were examined under both conditions. Basal locomotor activity was higher in isolated subjects of both strains in low light conditions, but under bright light conditions: this difference was only observed in Wistar rats. Locomotor stimulant effects of EtOH were only observed in isolation-reared rats. In the elevated plus maze, Fawn Hooded rats were more anxious than Wistar rats under low light conditions, but under bright light conditions, Wistar socials were less anxious than all of the other groups. Administration of 1.5 mg/kg EtOH produced an anxiolytic response in the elevated plus maze under bright light conditions in Fawn Hooded rats, but to a lesser degree Wistar rats, particularly Wistar isolates. In conclusion, although both strain and isolation-rearing had effects on locomotion and anxiety as well as the stimulatory and anxiolytic effects of EtOH, these effects appeared to be independent.