A three-dimensional self-opening intraneural peripheral interface (SELINE)
A three-dimensional self-opening intraneural peripheral interface (SELINE)
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DOI：
10.1088/1741-2560/12/1/016016
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发表时间：
2015-02-01
影响因子：
4
通讯作者：
Bossi, S.
中科院分区：
文献类型：
--
作者：
Cutrone, A.;Del Valle, J.;Bossi, S.
Objective.在这项研究中，我们提出了一种新的灵活的周围神经接口的自开神经接口（SELINE），在大鼠模型的开发和测试。Approach.这种聚酰亚胺基电极具有三维结构，可为神经提供锚固系统，并在植入后提供稳定性。这种几何形状是通过聚酰亚胺的塑性变形实现的。已进行机械和电化学表征以证明电极的完整性，并取得了非常好的结果。在大鼠体内急性实验期间，已经测试了SELINE用于神经束刺激的功能。制作慢性植入物以测试器械的生物相容性。主要结果。结果显示，SELINE显著改善了对神经的机械锚定。与普通平面横向电极相比，刺激稳定性显著增强，并且对于某些运动神经束，刺激选择性增加。慢性实验结果表明，SELINE既不产生坐骨神经的分支组织的变化，也不产生神经变性的迹象。意义所提出的三维电极为神经组织提供了有效的锚固系统，可以提高植入物在急性和慢性研究中的稳定性。
Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that provides an anchorage system to the nerve and confers stability after implant. This geometry has been achieved by means of the plastic deformation of polyimide. Mechanical and electrochemical characterizations have been performed to prove the integrity of the electrode with very good results. Functionality of SELINEs for fascicular stimulation has been tested during in vivo acute experiments in the rat. Chronic implants were made to test the biocompatibility of the device. Main results. Results showed that SELINEs significantly improve mechanical anchorage to the nerve. Stimulation stability is considerably enhanced compared to common planar transversal electrodes and stimulation selectivity is increased for some motor fascicles. Chronic experimental results showed that SELINEs neither produce changes in the fascicular organization of sciatic nerves nor signs of nerve degeneration. Significance. The presented three-dimensional electrode provides an effective anchorage system to the nervous tissue that can improve the stability of the implant for acute and chronic studies.