The cystine/glutamate antiporter: when too much of a good thing goes bad.
The cystine/glutamate antiporter: when too much of a good thing goes bad.
复制标题
胱氨酸/谷氨酸逆向转运蛋白：当太多的好东西变坏时。
DOI：
10.1172/jci76627
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Reissner,KathrynJ
中科院分区：
文献类型：
--
作者：
Reissner,KathrynJ
Glutamate excitotoxicity represents a major cellular component of ischemic brain injury. In this issue of theJCI, Soria and colleagues reveal that the cystine/glutamate exchanger is an important source of excitotoxic glutamate in response to ischemia induced by oxygen and glucose deprivation. As the exchanger is a primary determinant of both extracellular glutamate and intracellular glutathione, the findings from this study not only provide important insight into the mechanisms of brain ischemia but also demonstrate the complexity of the yin and yang of glutamate homeostasis and cellular redox balance.
