Cell delivery: from cell transplantation to organ engineering.
Cell delivery: from cell transplantation to organ engineering.
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DOI：
10.3727/096368910x508753
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发表时间：
2010
影响因子：
3.3
通讯作者：
Yarmush ML
中科院分区：
文献类型：
--
作者：
Soto-Gutierrez A;Yagi H;Uygun BE;Navarro-Alvarez N;Uygun K;Kobayashi N;Yang YG;Yarmush ML
来源于成体组织和干细胞的细胞群在治疗几种疾病方面具有很大的期望。已经做出了巨大的努力来从干细胞产生具有治疗效果的细胞。然而，很明显，开发递送这种细胞以诱导有效的移植、生长和功能的系统是真实的必要的。生物和人造支架因其在体外形成组织和促进体内移植时的潜在治疗应用而受到广泛关注。最终，更复杂的器官去细胞化方法已成功用于组织工程和再生医学应用。这些脱细胞的组织和器官似乎提供生物活性分子和生物诱导性质以诱导细胞的归巢、分化和增殖。脱细胞器官和干细胞的组合可以显著改善移植干细胞的存活、植入和命运控制，以及它们的最终临床效用，从而打开器官工程新时代的大门。
Cell populations derived from adult tissue and stem cells possess a great expectation for the treatment of several diseases. Great efforts have been made to generate cells with therapeutic impact from stem cells. However, it is clear that the development of systems to deliver such cells to induce efficient engraftment, growth and function is a real necessity. Biologic and artificial scaffolds have received significant attention for their potential therapeutic application when use to form tissues in vitro and facilitate engraftment in vivo. Ultimately more sophisticated methods for decellularization of organs have been successfully used in tissue engineering and regenerative medicine applications. These decellularized tissues and organs appear to provide bioactive molecules, and bioinductive properties to induce homing, differentiation and proliferation of cells. The combination of decellularized organs and stem cells may dramatically improve the survival, engraftment, and fate control of transplanted stem cells and their ultimate clinical utility opening the doors to a new era of organ engineering.