Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques
Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques
复制标题
中性部花青染料：用于淀粉样蛋白斑块的体内 NIR 荧光成像
DOI：
10.1039/c7cc05056a
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发表时间：
2017-09-14
影响因子：
4.9
通讯作者：
Zhang, Lei
中科院分区：
文献类型：
--
作者：
Yan, Jin-wu;Zhu, Jia-ying;Zhang, Lei
通过对经典阳离子花青支架IR-780的合理工程改造，首次开发了两种基于中性部花青的近红外荧光探针，用于淀粉样蛋白β斑块的体内成像。活体近红外成像显示，该探针可以穿透血脑屏障，并有效地区分活的转基因和野生型小鼠。
Two neutral merocyanine-based near-infrared fluorescent probes were for the first time developed through rational engineering of the classical cationic cyanine scaffold IR-780 for in vivo imaging of amyloid-beta plaques. In vivo NIRF imaging revealed that the probe could penetrate the blood-brain barrier and efficiently differentiate the living transgenic and wild-type mice.