Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats
Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats
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DOI：
10.1016/j.ejphar.2003.10.048
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发表时间：
2004-01-19
影响因子：
5
通讯作者：
LeBlanc, MH
中科院分区：
文献类型：
--
作者：
Feng, YZ;Fratkins, JD;LeBlanc, MH
雌激素受体调节剂三苯氧胺对成年大鼠具有神经保护作用。他莫昔芬能减轻幼鼠的脑损伤吗？将7日龄大鼠幼仔的右颈动脉永久性结扎，然后缺氧2.5小时（8%氧气）。缺氧前5分钟或复氧后5分钟腹腔注射他莫昔芬（10 mg/kg）或溶剂，并在第一次给药后6小时给予第二次给药。通过缺氧后22天右半球的重量不足以及大体和显微镜形态学来评估脑损伤。他莫昔芬预处理使脑重量损失从载体幼仔（n = 27）的21.5 +/-4.0%减少到经处理幼仔的2.6 +/-2.5%（n = 22，P < 0.05）。再氧合后5分钟的处理使脑重量损失从载体幼仔（n = 42）的27.5 +/-4.0%减少到处理幼仔的12.0 +/-3.9%（n = 30，P < 0.05）。他莫昔芬减轻新生大鼠脑损伤。(C)2003 Elsevier B. V.保留所有权利。
Tamoxifen, an estrogen receptor modulator, is neuroprotective in adult rats. Does tamoxifen reduce brain injury in the rat pup? Seven-day-old rat pups had the right carotid artery permanently ligated followed by 2.5 h of hypoxia (8% oxygen). Tamoxifen (10 mg/kg) or vehicle was given i.p. 5 min prior to hypoxia, or 5 min after reoxygenation, with a second dose given 6 h after the first. Brain damage was evaluated by weight deficit of the right hemisphere 22 days following hypoxia and gross and microscopic morphology. Tamoxifen pre-treatment reduced brain weight loss from 21.5 +/- 4.0% in vehicle pups (n = 27) to 2.6 +/- 2.5% in the treated pups (n = 22, P < 0.05). Treatment 5 min after reoxygenation reduced brain weight loss from 27.5 +/- 4.0% in vehicle pups (n = 42) to 12.0 +/- 3.9% in the treated pups (n = 30, P < 0.05). Tamoxifen reduces brain injury in the neonatal rat. (C) 2003 Elsevier B.V. All rights reserved.