Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.
Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.
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通过实验疼痛评估氙和一氧化二氮对人体镇痛效力的比较。
DOI：
10.1093/bja/81.5.742
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发表时间：
1998
影响因子：
9.8
通讯作者：
A. Zbinden
中科院分区：
文献类型：
--
作者：
S. Petersen‐Felix;M. Luginbühl;T. Schnider;M. Curatolo;L. Arendt;A. Zbinden
我们使用多模式实验疼痛测试和评估技术比较了MAC等效浓度的氙（10，20，30和40%）和一氧化二氮（15，30，45和60%）在人体中的镇痛效力。我们在一项随机、单盲、交叉研究中测试了12名健康志愿者。使用以下实验性疼痛测试：对重复刺激的伤害性反射;对最大努力止血带缺血的疼痛耐受性;电刺激;机械压力;和寒冷。还测量了反应时间。氙气和氧化亚氮对缺血、电刺激和机械刺激均产生镇痛作用，但对冷痛无镇痛作用。氙和一氧化二氮的MAC当量浓度没有差异。两者都以类似的方式增加了反应时间。氙气和一氧化二氮在大量志愿者中引起恶心和呕吐。
We have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique. We tested 12 healthy volunteers in a randomized, single-blind, crossover study. The following experimental pain tests were used: nociceptive reflex to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia; electrical stimulation; mechanical pressure; and cold. Reaction time was also measured. Xenon and nitrous oxide produced analgesia to ischaemic, electrical and mechanical stimulation, but not to cold pain. There was no difference in MAC-equivalent concentrations of xenon and nitrous oxide. Both increased reaction time in a similar manner. Xenon and nitrous oxide evoked nausea and vomiting in a large number of volunteers.
一氧化二氮对人和大鼠的神经毒性研究。
影响因子：
8.8
作者：
Dyck,PJ;Grina,LA;Lambert,EH;Calder,CS;Oviatt,K;Rehder,K;Lund,BA;Skau,KA
通讯作者：
Skau,KA