Effects of Dietary Casein and Adrenal Hormone on the Dietary Induction of α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase Activity in Rat
Effects of Dietary Casein and Adrenal Hormone on the Dietary Induction of α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase Activity in Rat
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膳食酪蛋白和肾上腺激素对膳食诱导大鼠α-氨基-β-羧基粘康酸-ε-半醛脱羧酶活性的影响
DOI：
10.1271/bbb1961.49.2431
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
K. Iwai
中科院分区：
文献类型：
--
作者：
T. Hayakawa;K. Iwai
本文研究了酪蛋白和肾上腺素对大鼠肝、肾α-氨基-β-羧基粘康酸-e-半醛脱羧酶（ACMSDase）活性的影响。在检查的饮食中的三个酪蛋白水平（7.5%、15%和30%）中，仅在无蛋白饮食三天后向正常大鼠饲喂30%酪蛋白饮食导致第二天早晨肝脏和肾脏中ACMSDase活性的显著增加。这种活性的增加程度在肝脏中高于肾脏。当大鼠在实验开始前6天切除肾上腺时，ACMSDase活性的饮食诱导消失。假手术组大鼠肝脏ACMSDase活性的饮食诱导与正常组一样高，而肾脏ACMSDase活性则消失。肾上腺切除大鼠注射泼尼松龙（具有糖皮质激素活性的合成肾上腺激素）可恢复肝脏ACMSDase活性的饮食诱导。正常大鼠的血清皮质酮水平在喂养期的最后一天保持最大值，然后逐渐下降，直到04：00，并倾向于高于那些喂食30%酪蛋白饮食的大鼠在喂食无蛋白饮食。这些结果表明，ACMSDase活性的饮食诱导发生时，只有当足够量的饮食酪蛋白被摄入的存在下，在生理上显着浓度的血清糖皮质激素在大鼠。
The effects of dietary casein and adrenal hormone on the dietary induction of α-amino-β-carboxymuconate-e-semialdehyde decarboxylase (ACMSDase) activity in rat liver and kidneys were examined. Of three levels of casein in the diet examined (7.5%, 15% and 30%), only the feeding of a 30% casein diet to normal rats after three days on a protein-free diet resulted in a significant increase in the activity of ACMSDase in liver and kidneys on the following morning. The degree of the increase in this activity was higher in the liver than the kidneys. Dietary induction of ACMSDase activity disappeared when rats were adrenalectomized six days prior to the start of the experiment. In sham-operated rats, dietary induction of liver ACMSDase activity was as high as that in normal rats, however, that in kidneys disappeared. Prednisolone (synthetic adrenal hormone with glucocorticoid activity) injection of adrenalectomized rats led to the recovery of the dietary induction of liver ACMSDase activity. Blood serum corticosterone levels in normal rats on the last day of the feeding period remained maximum and then decreased gradually until 04: 00, and tended to be higher in rats fed a protein-free diet than in those fed a 30% casein diet. These results suggest that the dietary induction of ACMSDase activity occurs only when a sufficient amount of dietary casein is ingested in the presence of a physiologically significant concentration of blood serum glucocorticoid in rats.