Redox Regulation in Cancer Cells during Metastasis.
Redox Regulation in Cancer Cells during Metastasis.
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DOI：
10.1158/2159-8290.cd-21-0558
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发表时间：
2021-11
期刊：
影响因子：
28.2
通讯作者：
Morrison SJ
中科院分区：
文献类型：
--
作者：
Tasdogan A;Ubellacker JM;Morrison SJ
转移是一个效率低下的过程，其中绝大多数癌细胞注定要死亡，部分原因是它们经历了氧化应激。转移性癌细胞通过与其肿瘤来源显著不同的不同环境迁移，导致氧化还原失衡。存活下来的罕见的转移细胞经历可逆的代谢变化，赋予氧化应激抗性。我们回顾了癌细胞在转移过程中氧化还原调节的变化。通过更好地理解这些机制，有可能开发出通过加剧癌细胞中的氧化应激来阻断疾病进展的促氧化剂疗法。氧化应激通常限制癌细胞在转移期间的存活，提高了用促氧化剂疗法抑制癌症进展的可能性。这是与抗氧化剂治疗患者相反的策略，这种方法在大型临床试验中恶化了结果。
Metastasis is an inefficient process in which the vast majority of cancer cells are fated to die, partly because they experience oxidative stress. Metastasizing cancer cells migrate through diverse environments that differ dramatically from their tumor of origin, leading to redox imbalances. The rare metastasizing cells that survive undergo reversible metabolic changes that confer oxidative stress resistance. We review the changes in redox regulation that cancer cells undergo during metastasis. By better understanding these mechanisms, it may be possible to develop pro-oxidant therapies that block disease progression by exacerbating oxidative stress in cancer cells. Oxidative stress often limits cancer cell survival during metastasis, raising the possibility of inhibiting cancer progression with pro-oxidant therapies. This is the opposite strategy of treating patients with antioxidants, an approach that worsened outcomes in large clinical trials.