Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia
Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia
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DOI：
10.1152/ajpregu.90384.2008
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发表时间：
2008-12-01
影响因子：
2.8
通讯作者：
Badoer, Emilio
中科院分区：
文献类型：
--
作者：
Chen, Feng;Dworak, Melissa;Badoer, Emilio
Chen F，Dworak M，Wang Y，Cham JL，Badoer E。下丘脑 PVN 在高热引起的肠系膜血流反射性减少中的作用。 Am J Physiol Regul Integr Comp Physiol 295：R1874-R1881，2008。首次发表于 2008 年 10 月 22 日； doi:10.1152/ajpregu.90384.2008.-下丘脑室旁核 (PVN) 是大脑中重要的整合中心。在本研究中，我们研究了PVN是否是肠系膜血管收缩的关键区域，通常伴随着核心体温的升高。监测麻醉大鼠的血压、心率、肠系膜血流量和血管电导。在对照大鼠中，核心体温升高至 41 摄氏度对血压没有显着影响，心率增加，肠系膜血流量减少 21%。在另一组大鼠中，将蝇蕈醇双侧（1 nmol/侧）显微注射到PVN中。与对照组相比，核心体温升高引起的血压和心率反应没有显着差异。然而，与对照动物相比，接受蝇蕈醇治疗的大鼠的肠系膜血流量并未因核心体温升高而下降。在另一组中，将蝇蕈醇显微注射到PVN以外的区域，升高核心体温引起肠系膜血流量的正常减少。结果表明，PVN 可能在高热引起的肠系膜血流反射性减少中发挥关键作用。
Chen F, Dworak M, Wang Y, Cham JL, Badoer E. Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia. Am J Physiol Regul Integr Comp Physiol 295: R1874-R1881, 2008. First published October 22, 2008; doi:10.1152/ajpregu.90384.2008.-The hypothalamic paraventricular nucleus ( PVN) is an important integrative center in the brain. In the present study, we investigated whether the PVN is a key region in the mesenteric vasoconstriction that normally accompanies an increase in core body temperature. Anesthetized rats were monitored for blood pressure, heart rate, mesenteric blood flow, and vascular conductance. In control rats, elevation of core body temperature to 41 degrees C had no significant effect on blood pressure, increased heart rate, and reduced mesenteric blood flow by 21%. In a separate group of rats, muscimol was microinjected bilaterally (1 nmol/side) into the PVN. Compared with the control group, there was no significant difference in the blood pressure and heart rate responses elicited by the increase in core body temperature. In contrast to control animals, however, mesenteric blood flow did not fall in the muscimol-treated rats in response to the elevation in core body temperature. In a separate group, in which muscimol was microinjected into regions outside the PVN, elevating core body temperature elicited the normal reduction in mesenteric blood flow. The results suggest that the PVN may play a key role in the reflex decrease in mesenteric blood flow elicited by hyperthermia.