Morphometric changes in the human pulmonary acinus during inflation
Morphometric changes in the human pulmonary acinus during inflation
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DOI：
10.1152/japplphysiol.00768.2011
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Woods, J. C.
中科院分区：
文献类型：
--
作者：
Hajari, A. J.;Yablonskiy, D. A.;Woods, J. C.
Hajari AJ、Yablonskiy DA、Sukstanskii AL、Quirk JD、Conradi MS、Woods JC。充气期间人肺腺泡的形态变化。 J Appl Physiol 112: 937-943, 2012。首次发表于 2011 年 11 月 17 日； doi:10.1152/japplphyol.00768.2011.-尽管对肺膨胀和紧缩机制进行了数十年的研究，但对于肺膨胀是由于新肺泡的募集还是由于肺泡和肺泡管的大小和/或形状的变化而发生，几乎没有达成共识。在这项研究中，我们通过 MRI 使用体内 He-3 肺形态测定法来测量 5 名健康受试者在三个吸气水平下的平均肺泡深度和肺泡管半径，并计算每个充气水平下的平均肺泡体积、表面积和肺泡总数。我们的结果表明，肺气体量增加 143 +/- 18% 期间，平均肺泡深度减少 21 +/- 5%，平均肺泡管半径增加 7 +/- 3%，肺泡总数增加 96 +/- 9%（结果为受试者之间的平均值 +/- SD；分别为 P < 0.001、P < 0.01 和 P < 0.00001，通过配对 t 检验）。因此，我们的结果表明，在健康人类受试者中，肺部膨胀主要通过肺泡募集，并且在较小程度上通过肺泡管的各向异性扩张。
Hajari AJ, Yablonskiy DA, Sukstanskii AL, Quirk JD, Conradi MS, Woods JC. Morphometric changes in the human pulmonary acinus during inflation. J Appl Physiol 112: 937-943, 2012. First published November 17, 2011; doi:10.1152/japplphysiol.00768.2011.-Despite decades of research into the mechanisms of lung inflation and deflation, there is little consensus about whether lung inflation occurs due to the recruitment of new alveoli or by changes in the size and/or shape of alveoli and alveolar ducts. In this study we use in vivo He-3 lung morphometry via MRI to measure the average alveolar depth and alveolar duct radius at three levels of inspiration in five healthy human subjects and calculate the average alveolar volume, surface area, and the total number of alveoli at each level of inflation. Our results indicate that during a 143 +/- 18% increase in lung gas volume, the average alveolar depth decreases 21 +/- 5%, the average alveolar duct radius increases 7 +/- 3%, and the total number of alveoli increases by 96 +/- 9% (results are means +/- SD between subjects; P < 0.001, P < 0.01, and P < 0.00001, respectively, via paired t-tests). Thus our results indicate that in healthy human subjects the lung inflates primarily by alveolar recruitment and, to a lesser extent, by anisotropic expansion of alveolar ducts.