Initiation of locomotor activity in spinal cats by epidural stimulation of the spinal cord.
Initiation of locomotor activity in spinal cats by epidural stimulation of the spinal cord.
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DOI：
10.1023/a:1022199214515
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发表时间：
2003-03-01
影响因子：
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通讯作者：
Lavrov, I A
中科院分区：
文献类型：
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作者：
Gerasimenko, Yu P;Avelev, V D;Lavrov, I A
本实验采用猫下段脊髓（T10-T12），观察了硬膜外刺激脊髓背侧对自发活动起始的影响。位于L4和L5节段之间的边界的区域被确定，刺激诱导自发活动。确定了有效激活步进运动发生器的脊髓硬膜外刺激参数。导致运动活动启动的硬膜外刺激被证明依赖于激活脊髓节段、节段间和本体脊髓反射系统的中央和外周机制。在脊髓硬膜外刺激中，背外侧索的本体脊髓系统在激活步进运动发生器中起主导作用。
Acute and chronic experiments on lower spinal (T10-T12) cats were performed to investigate the effects of epidural stimulation of the dorsal surface of the spinal cord on the initiation of locomotor activity. A zone located at the border between segments L4 and L5 was identified, stimulation of which induces locomotor activity. The parameters of epidural stimulation of the spinal cord effective in activating the stepping movement generator were identified. Epidural stimulation leading to the initiation of movement activity was shown to depend on intracentral and peripheral mechanisms activating the segmental, intersegmental and propriospinal reflex systems of the spinal cord. A leading role was demonstrated for the propriospinal system of the dorsolateral funiculi in activating the generators of stepping movements in epidural stimulation of the spinal cord.