Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics.
Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics.
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DOI：
10.1364/boe.3.002500
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Michaelian K
中科院分区：
文献类型：
--
作者：
Alwi R;Telenkov S;Mandelis A;Leshuk T;Gu F;Oladepo S;Michaelian K
在这项研究中，我们首次报道了二氧化硅涂层超顺磁性氧化铁纳米颗粒（SPION）作为生物医学光声成像造影剂的使用。利用频域光声相关（光声雷达），我们研究了纳米颗粒尺寸、浓度和生物介质（例如血清、羊血）对混浊介质中光声响应的影响。最大检测深度和最小可测量 SPION 浓度通过实验确定。对致密肌肉组织（禽类胸肌和鼠类四肢）中纳米粒子诱导的离体光学造影进行了评估，并证明了二氧化硅涂层 SPION 作为可能的光声造影剂的强大潜力。
In this study, we report for the first time the use of silica-coated superparamagnetic iron oxide nanoparticles (SPION) as contrast agents in biomedical photoacoustic imaging. Using frequency-domain photoacoustic correlation (the photoacoustic radar), we investigated the effects of nanoparticle size, concentration and biological media (e.g. serum, sheep blood) on the photoacoustic response in turbid media. Maximum detection depth and the minimum measurable SPION concentration were determined experimentally. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus and murine quadricept) was evaluated and the strong potential of silica-coated SPION as a possible photoacoustic contrast agents was demonstrated.