Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration.
Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration.
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DOI：
10.1016/0165-6147(90)90195-e
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发表时间：
1990-03
影响因子：
13.8
通讯作者：
Y. Liu;D. Storm
中科院分区：
文献类型：
--
作者：
Y. Liu;D. Storm
Neuromodulin is a neurospecific calmodulin binding protein that is implicated in neurite extension, axonal elongation and long-term potentiation.Yuechueng Liu and Daniel Stormpropose that neuromodulin binds and concentrates calmodulin on growth cone membranes and that stimulation of protein kinase C releases high local concentrations of calmodulin in the growth cone. Interactions between released calmodulin and cytoskeleton proteins may affect the polymerization, crosslinking and membrane attachment of cytoskeleton polymers. This local ‘softening’ of the membrane may be an initial event in filopodia formation and extension.
