Myocardial injury in hospitalized patients with COVID-19 infection-Risk factors and outcomes.
Myocardial injury in hospitalized patients with COVID-19 infection-Risk factors and outcomes.
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DOI：
10.1371/journal.pone.0247800
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Grossman E
中科院分区：
文献类型：
--
作者：
Efros O;Barda N;Meisel E;Leibowitz A;Fardman A;Rahav G;Klempfner R;Grossman E
住院患者的心肌损伤与不良预后相关。本研究旨在评估2019冠状病毒病（COVID-19）住院患者心肌损伤的危险因素及其预后价值。我们检索了2020年2月9日至8月28日期间在三级医疗中心内科住院的所有确诊为COVID-19的连续患者。共有559名确诊为COVID-19的成年患者在舍巴医疗中心住院，其中320人（57.24%）在入院24小时内接受了肌钙蛋白水平检测，91人（28.44%）水平升高。肌钙蛋白水平升高的预测因素是年龄（比值比[OR]，1.04; 95%置信区间[CI]，1.01-1.06），女性（OR，3.03; 95% CI 1.54-6.25）、低收缩压（OR，5.91; 95% CI 2.42-14.44）和肌酐水平升高（OR，2.88; 95% CI 1.44-5.73）。肌钙蛋白水平升高的患者的死亡风险（风险比[HR] 4.32，95% CI 2.08-8.99）和有创通气支持和死亡的复合结局（HR 1.96，95% CI 1.15-3.37）显著较高。总之，在COVID-19住院患者中，肌钙蛋白水平升高与预后不良相关。因此，肌钙蛋白水平可用作对COVID-19住院患者进行风险分层的额外工具和决策指南。
Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9th, 2020 to August 28th with a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06), female sex (OR, 3.03; 95% CI 1.54–6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42–14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44–5.73). The risk for death (hazard ratio [HR] 4.32, 95% CI 2.08–8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15–3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.
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影响因子：
15.8
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