The synthesis of molecular recognition polymer particles via miniemulsion polymerization
The synthesis of molecular recognition polymer particles via miniemulsion polymerization
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DOI：
10.1016/j.reactfunctpolym.2018.02.013
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发表时间：
2018-05-01
影响因子：
5.1
通讯作者：
Li, Xiaoyu
中科院分区：
文献类型：
--
作者：
Wang, Zehu;Qiu, Teng;Li, Xiaoyu
在这项工作中，我们展示了一种微乳液聚合策略来合成分子印迹聚合物（MIP）亚微米颗粒。双酚A （BPA）是一种内分泌干扰化学物质，被选为模板分子。将模板溶解在功能单体和交联剂的混合物中。通过超声乳化将单体混合物乳化成粒径约为100 nm的微乳液。在液滴中通过自由基聚合将特定位点固定到聚合物颗粒中。模板提取后，得到平均直径为138 nm的MIP颗粒。在选择性和竞争性结合实验中，对BPA具有良好的结合能力，验证了颗粒上识别位点的形成。得益于小颗粒尺寸和大表面积，MIP颗粒表现出加速的吸附动力学。该颗粒具有亚微米级尺寸，具有良好的双酚a识别精度和再结合效率，在环境和分析领域具有广阔的应用前景。
In this work, we demonstrate a miniemulsion polymerization strategy to synthesize molecularly imprinted polymer (MIP) submicron particles. Bisphenol A (BPA), an endocrine disrupting chemical, is chosen as the template molecule. The template was dissolved in the mixture of the functional monomer and crosslinking agent. The monomer mixture was emulsified into miniemulsion with the droplet diameter of about 100 nm via sonication. The specific sites were immobilized into polymer particles through the radical polymerization in the droplets. After the extraction of the template, MIP particles were obtained with an average diameter of 138 nm. The formation of recognition sites on the particles was validated by the excellent binding capability towards BPA in the selective and competitive binding experiments. Benefited from the small particle sizes and large surface areas, the MIP particles exhibit accelerated adsorption kinetics. The particles with submicron sizes, excellent BPA recognition accuracy and rebinding efficiency would be attractive in environmental and analytic fields for BPA decontamination.