Physical properties determining self-organization of motors and microtubules
Physical properties determining self-organization of motors and microtubules
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DOI：
10.1126/science.1059758
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发表时间：
2001-05-11
期刊：
影响因子：
56.9
通讯作者：
Karsenti, E
中科院分区：
文献类型：
--
作者：
Surrey, T;Nédélec, F;Karsenti, E
在真核细胞中，微管及其相关的马达蛋白可以组织成各种大规模的模式。使用一个简化的实验系统，结合计算机模拟，我们研究了浓度和动力学参数的电机如何有助于他们的集体行为。我们观察到自组织的一般稳态结构，如星，漩涡，和网络的相互连接的极点。我们确定的参数组合，确定这些结构中的每一个的生成。一般来说，这种方法可能会成为有用的相关的形态发生现象发生在一个生物系统的生物物理特性的组成部分。
In eukaryotic cells, microtubules and their associated motor proteins can be organized into various Large-scale patterns. Using a simplified experimental system combined with computer simulations, we examined how the concentrations and kinetic parameters of the motors contribute to their collective behavior. We observed self-organization of generic steady-state structures such as asters, vortices, and a network of interconnected poles. We identified parameter combinations that determine the generation of each of these structures. In general, this approach may become useful for correlating the morphogenetic phenomena taking place in a biological system with the biophysical characteristics of its constituents.