Glutathione levels modulate domoic acid-induced apoptosis in mouse cerebellar granule cells
Glutathione levels modulate domoic acid-induced apoptosis in mouse cerebellar granule cells
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DOI：
10.1093/toxsci/kfm236
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发表时间：
2007-12-01
影响因子：
3.8
通讯作者：
Costa, Lucio G.
中科院分区：
文献类型：
--
作者：
Giordano, Gennaro;White, Collin C.;Costa, Lucio G.
软骨藻酸对小鼠小脑颗粒神经元(CGN)的暴露可导致细胞死亡，其方式取决于软骨藻酸的浓度。软骨藻酸浓度高于0.1mM时，细胞损伤以坏死为主，而软骨藻酸暴露于较低浓度的软骨藻酸(
Exposure of mouse cerebellar granule neurons (CGNs) to domoic acid induced cell death, either by apoptosis or by necrosis, depending on its concentration. Necrotic damage predominated in response to domoic acid above 0.1 mu M. In contrast, cell injury with apoptotic features (assessed by Hoechst staining and DNA laddering assay) was evident after exposure to lower concentrations of domoic acid (