Betaine supplementation affects the cholesterol but not the lipid profile of pigs
Betaine supplementation affects the cholesterol but not the lipid profile of pigs
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DOI：
10.1002/ejlt.200900066
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发表时间：
2010-03-01
影响因子：
2.7
通讯作者：
Tirapicos, Jose L.
中科院分区：
文献类型：
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作者：
Martins, Jose M.;Neves, Jose A.;Tirapicos, Jose L.
本研究旨在探讨长期饲喂甜菜碱对阿连特哈诺猪胆固醇和血脂的影响。在相似的36 kg体重（BW）下，将饲喂商业（C）饮食的去势雄性和雌性猪分为两组：i）C组，食用C饮食;和ii）CB组，食用补充有lg/kg甜菜碱的C饮食。猪以近似100 kg BW屠宰。测定蛋白质、尿素、葡萄糖、TAG、磷脂、同型半胱氨酸、总胆固醇、LDL-胆固醇和HDL-胆固醇的空腹血浆浓度。分析肝脏TAG、磷脂、总胆固醇和游离胆固醇，以及M.半膜肌和背侧皮下脂肪。补充甜菜碱的猪呈现显著更高的TAG、磷脂、胆固醇和脂蛋白胆固醇的血浆浓度。背部皮下脂肪胆固醇浓度也显着高于在CB中比C猪。在肌肉和皮下脂肪组织的最丰富的FA谱（包括不饱和与饱和FA比）中未检测到处理之间的差异。这些数据表明，甜菜碱诱导血脂异常，并增加背部皮下脂肪中的胆固醇浓度，而不影响M。半膜肌和背侧皮下脂肪。
This study was undertaken to investigate the effects of long term betaine intake on the cholesterol and lipid profile of Alentejano (AL) pigs. At similar to 36 kg body weight (BW), castrated male and female pigs fed a commercial (C) diet, were divided into two groups: i) Group C, consuming the C diet; and ii) Group CB, consuming the C diet supplemented with 1 g/kg betaine. Pigs were slaughtered at similar to 100 kg BW. Fasting plasma concentrations of protein, urea, glucose, TAG, phospholipids, homocysteine, total and LDL- and HDL-cholesterol were determined. Liver TAG, phospholipids, and total and free cholesterol were analyzed, as well as total lipids, cholesterol contents, and fatty acid (FA) composition of M. semimembranosus and dorsal subcutaneous fat. Betaine supplemented pigs presented significantly higher plasma concentrations of TAG, phospholipids, cholesterol, and lipoprotein cholesterol. The dorsal subcutaneous fat cholesterol concentration was also significantly higher in CB than in C pigs. No differences were detected in the most abundant FA profile (including the unsaturated to saturated FA ratio) of muscle and subcutaneous fat tissues among treatments. These data suggest that betaine induces dyslipidemia, and increases cholesterol concentration in dorsal subcutaneous fat, without affecting the FA profile of M. semimembranosus and dorsal subcutaneous fat.