Molecular mechanism and therapy application of necrosis during myocardial injury.
Molecular mechanism and therapy application of necrosis during myocardial injury.
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心肌损伤坏死的分子机制及治疗应用
DOI：
10.1111/jcmm.13575
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发表时间：
2018-05
影响因子：
5.3
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Xu T;Ding W;Tariq MA;Wang Y;Wan Q;Li M;Wang J
坏死是一个古老的课题，近年来在研究领域获得了新的关注。毫无疑问，除了物理或化学刺激引起的细胞意外死亡外，有些坏死可以通过基因操纵来调节。程序性坏死的分子机制的最新进展显示了一个精细的调控网络，为人类疾病的治疗提供了新的靶点。心脏病严重危害我们的健康，患者死亡率高。心肌细胞的死亡被认为是心脏病发病的关键。尽管坏死可能在心肌细胞死亡中扮演比凋亡更重要的角色，但在过去的30年里，凋亡一直被认为是细胞程序性死亡的唯一形式，因此受到了广泛的关注。然而，程序性坏死和相关信号通路的最新发现拓宽了我们在程序性细胞死亡领域的视野，并促进了新的药理应用于心脏病的治疗。在这篇综述中，我们总结了这些信号通路的最新进展，并讨论了靶向坏死在心脏病治疗中的病理生理相关性和治疗意义。
Necrosis is an ancient topic which gains new attraction in the research area these years. There is no doubt that some necrosis can be regulated by genetic manipulation other than an accidental cell death resulting from physical or chemical stimuli. Recent advances in the molecular mechanism underlying the programmed necrosis show a fine regulation network which indicates new therapy targets in human diseases. Heart diseases seriously endanger our health and have high fatality rates in the patients. Cell death of cardiac myocytes is believed to be critical in the pathogenesis of heart diseases. Although necrosis is likely to play a more important role in cardiac cell death than apoptosis, apoptosis has been paid much attention in the past 30 years because it used to be considered as the only form of programmed cell death. However, recent findings of programmed necrosis and the related signalling pathways have broadened our horizon in the field of programmed cell death and promote new pharmacological application in the treatment of heart diseases. In this review, we summarize the advanced progress in these signalling pathways and discuss the pathos‐physiological relevance and therapeutic implication of targeting necrosis in heart diseases treatment.
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