Effects of Zinc Supplementation on the Survival of Patients Who Received Concomitant Chemotherapy and Radiotherapy for Advanced Nasopharyngeal Carcinoma: Follow-Up of a Double-Blind Randomized Study With Subgroup Analysis
Effects of Zinc Supplementation on the Survival of Patients Who Received Concomitant Chemotherapy and Radiotherapy for Advanced Nasopharyngeal Carcinoma: Follow-Up of a Double-Blind Randomized Study With Subgroup Analysis
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DOI：
10.1002/lary.20524
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发表时间：
2009-07-01
期刊：
影响因子：
2.6
通讯作者：
Lin, Shih-Wei
中科院分区：
文献类型：
--
作者：
Lin, Yung-Song;Lin, Li-Ching;Lin, Shih-Wei
目的/假设：据报道，膳食锌对治疗癌症有积极作用。本研究旨在探讨补锌对晚期鼻咽癌患者同时接受化疗和放疗（CCRT）提高生存率的影响。研究设计：一项双盲，安慰剂对照的临床研究，亚组analysis.Methods：34例III期和IV期鼻咽癌患者选自一项双盲，安慰剂对照的临床研究。所有患者均随机接受标准剂量（75 mg/天，持续2个月）的锌补充剂或安慰剂，与CCRT联合治疗。总的局部复发、转移和无病生存率定义为从首次治疗到死亡、局部复发或远处转移发生的时间。实验组患者的5年总体无局部和无疾病生存率高于安慰剂组患者（分别为P = 0.044、P = 0.007和P = 0.033）。然而，两组患者5年无鼻咽癌生存率无显著差异（P = 0.149）。结论：锌补充规定与CCRT的效果衰减局部肿瘤复发，提高了晚期鼻咽癌患者的总生存率。未能降低远处转移生存率可能部分与我们患者的更晚期疾病阶段有关。
Objectives/Hypothesis: Dietary zinc has been reported to have positive effects on treating carcinoma. This study examined the effects of zinc supplementation on the improved survival of patients with advanced nasopharyngeal carcinoma receiving concomitant chemotherapy and radiotherapy (CCRT).Study Design: A double-blind, placebo-controlled clinical study with subgroup analysis.Methods: Thirty-four patients with stages III and IV nasopharyngeal carcinoma were selected from a double-blind, placebo-controlled clinical study. All the patients were randomized to receive a standard dose (75 mg/day for 2 months) of zinc supplements or placebo, in conjunction with CCRT. The overall local recurrence, metastasis, and disease-free survivals were defined as the period between the time of first treatment to the time of death, local recurrence, or distant metastases occurred.Results: Patients in the experimental group exhibited a higher 5-year overall local-free and disease-free survival rate than the patients in the placebo group (P = .044, P = .007, and P = .033, respectively). However, no significant differences were found between both patient groups for the 5-year metastases-free survival rate (P = .149).Conclusions: Zinc supplementation prescribed in conjunction with CCRT effects attenuating local tumor recurrence and improves the overall survival of patients with advanced nasopharyngeal carcinoma. The failure to reduce distant metastasis survival might have been related in part to the more advanced disease stages in our patients.