Early breast cancer therapy and cardiovascular injury
Early breast cancer therapy and cardiovascular injury
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DOI：
10.1016/j.jacc.2007.06.037
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发表时间：
2007-10-09
影响因子：
24
通讯作者：
Mackey, John R.
中科院分区：
文献类型：
--
作者：
Jones, Lee W.;Haykowsky, Mark J.;Mackey, John R.
尽管最近在治愈性治疗方面的进展开始在早期乳腺癌中产生显着的生存率提高，但这些改善最终可能会因长期心血管死亡风险增加而减弱。本文回顾了乳腺癌辅助治疗对心血管影响的新证据，并提出了一个新的实体，我们称之为“多次打击”假说。生活方式的改变，特别是运动疗法，可以减轻这些不良影响的证据也进行了审查。这些问题对于心血管临床医生来说具有相当大的实际意义，因为心血管并发症高危人群的识别和干预可能会降低早期乳腺癌女性死亡率的主要原因。
Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy and proposes a new entity that we have labeled the "multiple-hit" hypothesis. The evidence that lifestyle modification, especially exercise therapy, may mitigate these adverse effects is also reviewed. These issues are of considerable practical importance for cardiovascular clinicians, as identification and intervention in those at high risk for cardiovascular complications may reduce a major cause of mortality in women with early breast cancer.