Dietary essential fatty acids and the decline in peptic ulcer disease--a hypothesis.
Dietary essential fatty acids and the decline in peptic ulcer disease--a hypothesis.
复制标题
膳食必需脂肪酸和消化性溃疡病的减少——一个假设。
作者：
Hollander,D;Tarnawski,A
消化性溃疡病的发病率和毒力在过去几十年中一直在下降。在过去的20年里，美国、英格兰和威尔士2因十二指肠溃疡或胃溃疡而住院的人数一直在下降。与此同时，消化性溃疡病的外科手术数量也有所下降，甚至在使用西咪替丁之前也是如此。3 4最重要的是，在过去几十年中，因消化性溃疡疾病而导致的年龄性别特定死亡率也在下降。[8]例如，在苏格兰，男性在50岁时因十二指肠溃疡病而死亡的比率从1930年的154/100万下降到1976年的24/100万。[5]英国的类似数字表明，死亡率从1930年的百万分之109下降到1976年的百万分之16。[8]在美国，生命第五个十年的死亡率从1921年的百万分之40下降到1976年的百万分之7。[8]胃溃疡病和消化性溃疡病的死亡率也有类似的下降在女人身上。1 258消化性溃疡发病率、严重程度和死亡率下降的原因是什么？人们提出了许多假说来解释这一现象。9-1一个尚未被考虑的因素是膳食必需脂肪酸和胃十二指肠粘膜的自然防御机制之间的相互作用和消耗量的增加。越来越多的证据表明，抗溃疡的内在防御中的一个主要因素是胃十二指肠粘膜内源性加工主要为E组的Escherlandins。12这些Grostaglandins
The incidence and virulence of peptic ulcer disease have been declining for the past few decades. Hospital admissions due to duodenal or gastric ulcer have been declining in the United States and in England and Wales2 for the past 20 years. In parallel, the number of surgical operations for peptic ulcer disease has also declined, even before the introduction of cimetidine. 3 4 Most importantly, the age-sex-specific death rates due to peptic ulcer disease have also been declining during thepast few decades.. 8 For example, the death rate due to duodenal ulcer disease in men intheir fifth decade declined from 154 per million in 1930 to 24 per million in 1976 in Scotland. 5 Similar figures from England show a decline in death rate from 109 per million in 1930 to 16 per million in 1976.8 In the United States the decline in death rates in the fifth decade of life was from 40 per million in 1921 to seven permillion in 1976.8 A similar decrease in the mortality rate has been recorded in gastric ulcer disease and in peptic ulcer disease in women. 1 258What are the factors which would account for the decreased incidence, severity and mortality of peptic ulcer disease? Many hypotheses have been advanced to account for this phenomenon. 9-1 One factor that has not been considered is the increased consumption of, andinteraction between, dietary essential fatty acids and the natural defence mechanisms of the gastroduodenal mucosa. Evidence is accumulating that a major factor in the intrinsic defence against ulceration is the endogenous elaboration of prostaglandins, mainly of the E group, by the gastroduodenal mucosa. 12 These grostaglandins