Spatiotemporal analysis of invasive meningococcal disease, Germany
Spatiotemporal analysis of invasive meningococcal disease, Germany
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DOI：
10.3201/eid1211.060682
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发表时间：
2006-11-01
影响因子：
11.8
通讯作者：
Vogel, Ulrich
中科院分区：
文献类型：
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作者：
Elias, Johannes;Harmsen, Dag;Vogel, Ulrich
脑膜炎球菌可引起聚集性疾病。通过PorA和FetA的血清组化和序列分型对来自德国超过42个月的1，616名患者的样本进行分型，并产生高度多样化的数据集（Simpson指数0.963）。以自动方式应用回顾性时空扫描统计（SaTScan）来识别由PorA的血清群可变区（VR）VR1和VR2以及FetA的VR定义的每个精细型的聚类。共有26个显著聚类（p
Meningococci can cause clusters of disease. Specimens from 1,616 patients in Germany obtained over 42 months were typed by serogrouping and sequence typing of PorA and FetA and yielded a highly diverse dataset (Simpson's index 0.963). A retrospective spatiotemporal scan statistic (SaTScan) was applied in an automated fashion to identify clusters for each finetype defined by serogroup variable region (VR) VR1 and VR2 of the PorA and VR of the FetA. A total of 26 significant clusters (p