Mechanosensitive channels: insights from continuum-based simulations.
Mechanosensitive channels: insights from continuum-based simulations.
复制标题
机械敏感通道：基于连续的模拟的见解。
DOI：
10.1007/s12013-008-9024-5
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发表时间：
2008
影响因子：
2.6
通讯作者：
Chen, Xi
中科院分区：
文献类型：
--
作者：
Tang, Yuye;Yoo, Jejoong;Yethiraj, Arun;Cui, Qiang;Chen, Xi
Mechanotransduction plays an important role in regulating cell functions and it is an active topic of research in biophysics. Despite recent advances in experimental and numerical techniques, the intrinsic multiscale nature imposes tremendous challenges for revealing the working mechanisms of mechanosensitive channels. Recently, a continuum-mechanics based hierarchical modeling and simulation framework has been established and applied to study the mechanical responses and gating behaviors of a prototypical mechanosensitive channel, the mechanosensitive channel of large conductance (MscL) in bacteria Escherichia coli (E. coli), from which several putative gating mechanisms have been tested and new insights deduced. This article reviews these latest findings using the continuum mechanics framework and suggests possible improvements for future simulation studies. This computationally efficient and versatile continuum-mechanics based protocol is poised to make contributions to the study of a variety of mechanobiology problems.
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影响因子：
3.4
作者：
Gullingsrud, J;Schulten, K
通讯作者：
Schulten, K
影响因子：
16.8
作者：
Edwards, MD;Li, YZ;Booth, IR
通讯作者：
Booth, IR
DOI：
10.1085/jgp.200409198
发表时间：
2005-02
期刊：
The Journal of general physiology
影响因子：
--
作者：
Akitake B;Anishkin A;Sukharev S
通讯作者：
Sukharev S
影响因子：
3.4
作者：
Gu, LQ;Liu, WH;Martinac, B
通讯作者：
Martinac, B
影响因子：
16.8
作者：
Akitake, Bradley;Anishkin, Andriy;Sukharev, Sergei
通讯作者：
Sukharev, Sergei