Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis
Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis
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DOI：
10.1098/rspb.2010.0010
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发表时间：
2010-07-07
影响因子：
4.7
通讯作者：
Hudson, Peter J.
中科院分区：
文献类型：
--
作者：
Long, Grainne H.;Karanikas, Alexia T.;Hudson, Peter J.
尽管50多年来在全人口范围内进行了疫苗接种，但百日咳的发病率仍在上升。虽然百日咳博德特氏菌被认为是人类百日咳的主要病原体，但副百日咳博德特氏菌感染并不罕见。广泛使用的无细胞百日咳疫苗（aP）仅由B组成。百日咳抗原对B几乎没有效力或没有效力。副百日咳。在这里，我们问aP疫苗接种如何影响共感染啮齿动物宿主内博德特氏菌属物种之间的竞争性相互作用，从而影响aP驱动的宿主内选择的强度和方向。我们发现aP疫苗有助于清除B。但导致B增加约40倍。副百日咳肺集落形成单位（CFU）。这种疫苗介导的对B.副百日咳不是竞争性释放的结果; B.无论感染是单一的还是混合的，在aP-中的副百日咳CFU相对于假疫苗接种的宿主更高。此外，我们表明，aP疫苗接种阻碍宿主对B的免疫。百日咳-测量为减少的肺部炎症和中性粒细胞反应。因此，我们得出结论，aP疫苗接种干扰了B的最佳清除。副百日咳，并提高这种病原体的性能。我们的数据提出了广泛的aP疫苗接种可能会使宿主对B更敏感的可能性。副百日咳感染。
Despite over 50 years of population-wide vaccination, whooping cough incidence is on the rise. Although Bordetella pertussis is considered the main causative agent of whooping cough in humans, Bordetella parapertussis infections are not uncommon. The widely used acellular whooping cough vaccines (aP) are comprised solely of B. pertussis antigens that hold little or no efficacy against B. parapertussis. Here, we ask how aP vaccination affects competitive interactions between Bordetella species within co-infected rodent hosts and thus the aP-driven strength and direction of in-host selection. We show that aP vaccination helped clear B. pertussis but resulted in an approximately 40-fold increase in B. parapertussis lung colony-forming units (CFUs). Such vaccine-mediated facilitation of B. parapertussis did not arise as a result of competitive release; B. parapertussis CFUs were higher in aP-relative to sham-vaccinated hosts regardless of whether infections were single or mixed. Further, we show that aP vaccination impedes host immunity against B. parapertussis-measured as reduced lung inflammatory and neutrophil responses. Thus, we conclude that aP vaccination interferes with the optimal clearance of B. parapertussis and enhances the performance of this pathogen. Our data raise the possibility that widespread aP vaccination can create hosts more susceptible to B. parapertussis infection.