Identification of a T cell hybridoma which produces extraordinary quantities of macrophage activating factor.
Identification of a T cell hybridoma which produces extraordinary quantities of macrophage activating factor.
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鉴定产生大量巨噬细胞激活因子的 T 细胞杂交瘤。
DOI：
10.1007/978-1-4684-4394-3_52
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发表时间：
1982
影响因子：
--
通讯作者：
Katz,DH
中科院分区：
文献类型：
--
作者：
Schreiber,RD;Altman,A;Katz,DH
现在普遍认为，在某些条件下，巨噬细胞可以表达针对多种肿瘤细胞的效应细胞功能（1，2）。目前的证据表明，巨噬细胞杀肿瘤反应是由T细胞产物启动和/或增强的，称为巨噬细胞活化因子或MAF（3-7）。MAF被认为以这样的方式改变或“引发”巨噬细胞，使得其响应于第二或“触发”信号，其最终激活细胞的杀肿瘤潜力（8-12）。
It is now generally accepted that under certain conditions the macrophage can express effector cell function toward a variety of neoplastic cells (1,2). Current evidence indicates that the macrophage tumoricidal response is initiated and/or augmented by a T cell product, denoted as macrophage activating factor or MAF (3–7). MAF is thought to alter or “prime” the macrophage in such a way as to make it responsive to a second or “triggering” signal which ultimately activates the tumoricidal potential of the cell (8–12).