TEMPERATURE FREQUENCY EQUIVALENCE OF THE VISCOELASTIC PROPERTIES OF ANHYDROUS LANOLIN USP
TEMPERATURE FREQUENCY EQUIVALENCE OF THE VISCOELASTIC PROPERTIES OF ANHYDROUS LANOLIN USP
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DOI：
10.1002/jps.2600720424
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发表时间：
1983-01-01
影响因子：
3.8
通讯作者：
SIMONELLI, AP
中科院分区：
文献类型：
--
作者：
RADEBAUGH, GW;SIMONELLI, AP
将一种新颖的药物半固体数据分析方法应用于无水羊毛脂USP的动态力学数据。结果表明，在较宽的温度和剪切频率范围内测得的粘弹性参数可以叠加。在低温(T)和频率(V)下获得的弹性模数(G‘)和粘性模数(G“)与在高Tandv下获得的模数相等。利用在不同温度下获得的剪切频率数据的经验移位来产生G’和G”-Vmaster曲线(恒温下的全对数模数对数频率行为)。简化变量法与Arrhenius型关系相结合，在计算主要力学转变所涉及的结构过程的激活能时被证明是有用的。
Methods of data analysis novel to pharmaceutical semisolids have been applied to the dynamic mechanical data obtained for anhydrous lanolin USP. It was found that the viscoelastic parameters determined over a wide range of temperatures and shear frequencies could be superposed. Elastic moduli (G′), and viscous moduli (G″) obtained at low temperatures (T) and frequencies (v), were equivalent to moduli obtained at highTandv.Empirical shifts of modulusversusshear frequency data obtained at different temperatures were used to produceG′ and G″versus vmaster curves (complete log modulusversuslog frequency behavior at a constant temperature). A method of reduced variables, in conjunction with an Arrhenius‐type relation, proved useful in calculating the energy of activation for the structural processes involved in a major mechanical transition.