Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness.
Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness.
复制标题
DOI：
10.1016/j.juro.2012.01.123
复制
发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Interstitial Cystitis Collaborative Research Network
中科院分区：
文献类型：
--
作者：
FitzGerald MP;Payne CK;Lukacz ES;Yang CC;Peters KM;Chai TC;Nickel JC;Hanno PM;Kreder KJ;Burks DA;Mayer R;Kotarinos R;Fortman C;Allen TM;Fraser L;Mason-Cover M;Furey C;Odabachian L;Sanfield A;Chu J;Huestis K;Tata GE;Dugan N;Sheth H;Bewyer K;Anaeme A;Newton K;Featherstone W;Halle-Podell R;Cen L;Landis JR;Propert KJ;Foster HE Jr;Kusek JW;Nyberg LM;Interstitial Cystitis Collaborative Research Network
To determine the efficacy and safety of pelvic floor Myofascial Physical Therapy (MPT) in women with newly-symptomatic IC/PBS, as compared to Global Therapeutic Massage (GTM). A randomized controlled trial of 10 scheduled treatments of MPT vs. GTM was performed at 11 clinical centers located in North America. We recruited women with IC/PBS with demonstrable pelvic floor tenderness on physical examination and a limitation of no more than 3 years symptom duration. The primary outcome was the proportion of responders defined as ‘moderately improved’ or ‘markedly improved’ in overall symptoms compared to baseline on a 7-point scale Global Response Assessment (GRA). Secondary outcomes included ratings for pain, urgency, frequency; the O'Leary-Sant IC Symptom and Problem Index (ICSI/ICPI) and reports of adverse events. We compared response rates between treatment arms using the exact conditional version of the Mantel-Haenszel test to control for clustering by clinical center. For secondary efficacy outcomes, cross-sectional descriptive statistics and changes from baseline were calculated. Eighty-one women randomized to the two treatment groups had similar symptoms at baseline. The GRA response rate was 26% in the GTM group and 59% in the MPT group (p=0.0012). Pain, urgency, and frequency ratings and in ICSI/ICPI decreased in both groups during follow-up and were not significantly different between the groups. Pain was the most common adverse event, occurring at similar rates in both groups. There were no serious adverse events reported. A significantly higher proportion of women with IC/PBS reponded to treatment with MPT than with GTM. MPT may be a beneficial therapy in women with this syndrome.
登录
查看更多内容
影响因子：
6.6
作者：
Shoskes, Daniel A.;Berger, Richard;Zeitlin, Scott
通讯作者：
Zeitlin, Scott
DOI：
10.1007/s00192-003-1050-7
发表时间：
2003-10-01
期刊：
INTERNATIONAL UROGYNECOLOGY JOURNAL AND PELVIC FLOOR DYSFUNCTION
影响因子：
--
作者：
FitzGerald, MP;Kotarinos, R
通讯作者：
Kotarinos, R
影响因子：
2.1
作者：
Clemens, JQ;Nadler, RB;Bushman, W
通讯作者：
Bushman, W
影响因子：
6.6
作者：
Weiss, JM
通讯作者：
Weiss, JM
影响因子：
--
作者：
LILIUS, HG;ORAVISTO, KJ;VALTONEN, EJ
通讯作者：
VALTONEN, EJ