Breastfeeding is Associated with Reduced Childhood Hospitalization: Evidence from a Scottish Birth Cohort (1997-2009)
Breastfeeding is Associated with Reduced Childhood Hospitalization: Evidence from a Scottish Birth Cohort (1997-2009)
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DOI：
10.1016/j.jpeds.2014.11.013
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发表时间：
2015-03-01
影响因子：
5.1
通讯作者：
Stockton, Diane L.
中科院分区：
文献类型：
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作者：
Ajetunmobi, Omotomilola M.;Whyte, Bruce;Stockton, Diane L.
目的评估苏格兰6-8周龄婴儿喂养模式与儿童住院的风险。研究设计一项回顾性人群水平研究，基于出生、死亡、孕产、婴儿健康、儿童健康监测、以及1997年至2009年期间在苏格兰出生的独生子女的入院记录（n = 502948），随访至2012年3月。使用描述性分析、Kaplan Meier检验和考克斯回归来量化婴儿喂养方式与儿童因呼吸道、胃肠道和尿路感染以及研究期间其他常见儿童疾病住院风险之间的关联。研究期间。结果在生命的前6个月内，在配方奶粉喂养的婴儿中，因常见儿童疾病住院的风险比（HR）更大（HR 1.40; 95% CI 1.35-1.45）和混合喂养的婴儿（HR 1.18; 95% CI 1.11-1.25）与纯母乳喂养的婴儿相比，在调整父母、母亲和婴儿健康特征后。在出生后的第一年及以后，观察到配方奶粉喂养的婴儿因儿童时期报告的一系列个别疾病住院的相对风险更大，这些疾病包括胃肠道、呼吸道和尿路感染、中耳炎、发烧、哮喘、糖尿病和龋齿。我们发现，在6-8周大的苏格兰婴儿中，非纯母乳喂养的婴儿在儿童早期因一系列常见儿童疾病住院的风险更大。
Objective To evaluate the risk of childhood hospitalization associated with infant feeding patterns at 6-8 weeks of age in Scotland.Study design A retrospective population level study based on the linkage of birth, death, maternity, infant health, child health surveillance, and admission records for children born as single births in Scotland between 1997 and 2009 (n = 502 948) followed up to March 2012. Descriptive analyses, Kaplan Meier tests, and Cox regression were used to quantify the association between the mode of infant feeding and risk of childhood hospitalization for respiratory, gastrointestinal, and urinary tract infections, and other common childhood ailments during the study period.Results Within the first 6 months of life, there was a greater hazard ratio (HR) of hospitalization for common childhood illnesses among formula-fed infants (HR 1.40; 95% CI 1.35-1.45) and mixed-fed infants (HR 1.18; 95% CI 1.11-1.25) compared with infants exclusively breastfed after adjustment for parental, maternal, and infant health characteristics. Within the first year of life and beyond, a greater relative risk of hospitalization was observed among formula-fed infants for a range of individual illnesses reported in childhood including gastrointestinal, respiratory, and urinary tract infections, otitis media, fever, asthma, diabetes, and dental caries.Conclusions Using linked administrative data, we found greater risks of hospitalization in early childhood for a range of common childhood illnesses among Scottish infants who were not exclusively breastfed at 6-8 weeks of age.