AUTOIMMUNE PHENOMENA IN ATAXIA TELANGIECTASIA
AUTOIMMUNE PHENOMENA IN ATAXIA TELANGIECTASIA
复制标题
DOI：
10.1016/s0022-3476(71)80353-0
复制
发表时间：
1971-01-01
影响因子：
5.1
通讯作者：
HONG, R
中科院分区：
文献类型：
--
作者：
AMMANN, AJ;HONG, R
对18例共济失调毛细血管扩张症患者进行了自身免疫现象的研究。抗甲状腺球蛋白抗体、抗平滑肌抗体、抗顶细胞抗体、抗横纹肌抗体、抗小管基底膜抗体、抗线粒体抗体、抗胆小管抗体和抗Ig G抗体阳性率为45%(8/18)。共济失调毛细血管扩张症患者的某些临床和实验室特征与出生时切除胸腺的动物相似，这表明胸腺可能直接或继发性地在自身免疫现象的发展中发挥作用，容易被一种未知的病原体慢性感染。
Eighteen patients with ataxia telangiectasia were studied for evidence of autoimmune phenomena. Forty-five per cent (8/18) were positive for one or more of the following autoantibodies: antithyroglobulin, antismooth muscle, antiparietal cell, antistriated muscle, antitubular basement membrane, antimitochondria, antibile canaliculi, and anti-IgG. The similarity of certain of the clinical and laboratory features of patients with ataxia telangiectasia to those found in animals thymectomized at birth suggests that the thymus may play a role in the development of autoimmune phenomena, either directly or secondarily by predisposing to chronic infection with an as yet unknown agent.