Agar/κ-carrageenan/montmorillonite nanocomposite hydrogels for wound dressing applications
Agar/κ-carrageenan/montmorillonite nanocomposite hydrogels for wound dressing applications
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DOI：
10.1016/j.ijbiomac.2020.09.048
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发表时间：
2020-12-01
影响因子：
8.2
通讯作者：
Tunc, Sibel
中科院分区：
文献类型：
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作者：
Polat, Tulin Gurkan;Duman, Osman;Tunc, Sibel
本研究制备了琼脂/卡拉胶/蒙脱土(MMT)水凝胶，考察了其作为创面敷料材料的适用性，并考察了蒙脱石用量对琼脂/卡拉胶水凝胶材料某些性能的影响。用扫描电子显微镜、透射电子显微镜和差示扫描量热仪对水凝胶进行了表征。当蒙脱土在水凝胶基质中的含量从0%增加到5%时，水凝胶材料的分解温度从256.6℃提高到262.1℃。水凝胶在d-葡萄糖溶液中的溶胀量(2682%)明显高于生理盐水溶液(937%)、合成尿液(746%)和模拟创面液(563%)。对水凝胶系统中止痛药盐酸利多卡因(LDC)和抗生素氯霉素(CLP)的释放研究表明，LDC和CLP在水凝胶中的释放量可以通过凝胶基质中蒙脱土的含量来控制。水凝胶样品在4℃保存6个月后，药物浓度无明显变化。含有CLP的水凝胶材料对大肠杆菌和金黄色葡萄球菌具有良好的抗菌活性。细胞毒性试验结果表明，该水凝胶与MG-63细胞具有良好的生物相容性。测得含有LDC和CLP的琼脂/卡拉胶水凝胶和含有5%蒙脱土的琼脂/卡拉胶/蒙脱土水凝胶的极限压应力分别为38.30 kPa和47.70 kpa。实验结果表明，制备的琼脂/卡拉胶和琼脂/卡拉胶/蒙脱土水凝胶具有很大的应用潜力。(C)2020爱思唯尔B.V.保留所有权利。
In this study, agar/kappa-carrageenan/montmorillonite (MMT) hydrogels were prepared to examine their usability as wound dressing materials and to see the effect of MMT amount on some properties of agar/kappa-carrageenan hydrogel materials. Hydrogels were characterized by SEM-EDX, TEM and DSC analyses. By increasing the MMT content within hydrogel matrix from 0% to 5%, the decomposition temperature of the hydrogel material was increased from 256.6 degrees C to 262.1 degrees C. Swelling amount of hydrogels in d-glucose solution (2682%) was found to be much higher compared with other physiological solutions such as physiological saline solution (937%), synthetic urine solution (746%) and simulated wound fluid (563%). The release studies of analgesic lidocaine hydrochloride (LDC) and antibiotic chloramphenicol (CLP) drugs from hydrogel systems demonstrated that the release amount of LDC and CLP from hydrogels could be controlled by MMT amount within hydrogel matrix. The concentrations of drugs within hydrogel sample stored at 4 degrees C for 6 months did not exhibit a significant change. Hydrogel materials containing CLP exhibited good antibacterial activity against E. coli and S. aureus. Cytotoxicity test results indicated that hydrogels were biocompatible with MG-63 cells. The ultimate compressive stress of agar/kappa-carrageenan hydrogel with LDC and CLP and agar/kappa-carrageenan/MMT hydrogel including 5% MMT with LDC and CLP was measured as 38.30 kPa and 47.70 kPa, respectively. The experimental results revealed that prepared agar/kappa-carrageenan and agar/kappa-carrageenan/MMT hydrogels have great potential for wound care applications. (C) 2020 Elsevier B.V. All rights reserved.