Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery
Change in abdominal, but not femoral subcutaneous fat CT-radiodensity is associated with improved metabolic profile after bariatric surgery
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DOI：
10.1016/j.numecd.2020.07.010
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发表时间：
2020-11-27
影响因子：
3.9
通讯作者：
Nuutila, Pirjo
中科院分区：
文献类型：
--
作者：
Dadson, Prince;Rebelos, Eleni;Nuutila, Pirjo
背景和目标：计算机断层扫描（CT）衍生的脂肪组织放射密度代表了脂质沉积和肥胖相关代谢疾病风险的潜在非侵入性替代标志物。我们研究了减肥手术对病态肥胖患者腹部和股部CT脂肪放射密度的影响及其与循环代谢物的关系。方法和结果：我们检查了23名在减肥手术前和手术后6个月接受CT成像的病态肥胖妇女。15名健康非肥胖女性作为对照组。测量所有参与者的腹部皮下脂肪组织（SAT）和内脏脂肪组织（VAT）以及股部SAT、脂肪组织质量的放射密度。通过NMR测量循环代谢物。基线时，肥胖患者腹部脂肪库的放射密度低于对照组。令人惊讶的是，与对照组相比，肥胖组股骨SAT的放射密度更高。在腹部SAT贮库中，放射密度与SAT质量密切相关（r =-0.72，p < 0.001）。术后腹部脂肪放射密度显著增加（均P < 0.01），而股骨SAT放射密度保持不变。与手术前值相比，循环ApoB/ApoA-I、亮氨酸、缬氨酸和GlycA降低，而甘氨酸水平显著增加（所有p < 0.05）。腹部脂肪放射密度的增加与ApoB/ApoA-I比值、亮氨酸和GlycA水平的降低呈负相关（均p < 0.05）。腹部脂肪密度的增加与脂肪堆积量的减少呈显著正相关（r =-0.66，p = 0.002）。结论：腹部脂肪堆积量高，股部皮下脂肪含量低是病态肥胖的重要病理生理特征。非腹部皮下脂肪在肥胖发病中的作用有待进一步研究。临床试验注册号：NCT 01373892。(C)2020年意大利糖尿病学会，意大利动脉粥样硬化研究学会，意大利人类营养学会和临床医学和外科学系，费德里科二世大学。由爱思唯尔公司出版
Background and aims: Computed tomography (CT)-derived adipose tissue radiodensity represents a potential noninvasive surrogate marker for lipid deposition and obesity-related metabolic disease risk. We studied the effects of bariatric surgery on CT-derived adipose radiodensities in abdominal and femoral areas and their relationships to circulating metabolites in morbidly obese patients. Methods and results: We examined 23 morbidly obese women who underwent CT imaging before and 6 months after bariatric surgery. Fifteen healthy non-obese women served as controls. Radiodensities of the abdominal subcutaneous (SAT) and visceral adipose tissue (VAT), and the femoral SAT, adipose tissue masses were measured in all participants. Circulating metabolites were measured by NMR. At baseline, radiodensities of abdominal fat depots were lower in the obese patients as compared to the controls. Surprisingly, radiodensity of femoral SAT was higher in the obese as compared to the controls. In the abdominal SAT depot, radiodensity strongly correlated with SAT mass (r =-0.72, p < 0.001). After surgery, the radiodensities of abdominal fat increased significantly (both p < 0.01), while femoral SAT radio density remained unchanged. Circulating ApoB/ApoA-I, leucine, valine, and GlycA decreased, while glycine levels significantly increased as compared to pre-surgical values (all p < 0.05). The increase in abdominal fat radiodensity correlated negatively with the decreased levels of ApoB/ApoA-I ratio, leucine and GlycA (all p < 0.05). The increase in abdominal SAT density was significantly correlated with the decrease in the fat depot mass (r =-0.66, p = 0.002).Conclusion: Higher lipid content in abdominal fat depots, and lower content in femoral subcutaneous fat, constitute prominent pathophysiological features in morbid obesity. Further studies are needed to clarify the role of non-abdominal subcutaneous fat in the pathogenesis of obesity. Clinical trial registration number: NCT01373892. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V.