TISSUE-RESPONSE TO MECHANICAL VIBRATIONS FOR SONOELASTICITY IMAGING
TISSUE-RESPONSE TO MECHANICAL VIBRATIONS FOR SONOELASTICITY IMAGING
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DOI：
10.1016/0301-5629(90)90003-u
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发表时间：
1990-01-01
影响因子：
2.9
通讯作者：
LERNER, RM
中科院分区：
文献类型：
--
作者：
PARKER, KJ;HUANG, SR;LERNER, RM
“声弹性成像”的目的是区分正常软组织和硬病变。这是通过测量然后显示组织内的区域的超声多普勒频谱来完成的，所述组织内的区域被机械地施加低频（20-1000 Hz）振动。该技术的分辨率和灵敏度最终取决于超声多普勒检测的空间分辨率、组织的低频机械特性以及具有硬肿瘤内含物的分层、不均匀区域的振动响应以及由皮肤、骨骼和其他区域的存在设置的复杂边界条件。初步调查测量了一些组织刚度参数，并将其应用于NASTRAN有限元分析，以模拟盆腔中的前列腺肿瘤。测量结果表明，肿瘤和软组织（如肌肉和前列腺）的弹性模量之间存在明智的分离。NASTRAN分析表明，能够根据振动幅度的模式区分不同弹性区域。在100-300 Hz频带内改变振动频率的能力似乎在可视化组织中的小的刚性内含物的模拟和实验中特别有帮助。初步结果支持的假设，声弹性成像可以提供有用的信息，否则无法获得的组织特性。
The goal of "sonoelasticity imaging" is to differentiate between normal soft tissues hard lesions. This is done by measuring and then displaying the ultrasound Doppler spectrum of regions within tissues which are mechanically forced with low frequency (20-1000 Hz) vibrations. The resolution and sensitivity of the technique ultimately rest on the spatial resolution of ultrasound Doppler detection, the low frequency mechanical properties of tissues, and the vibration response of layered, inhomogeneous regions with hard tumor inclusions and complicated boundary conditions set by the presence of skin, bones and other regions. An initial investigation has measured some tissue stiffness parameters, and applied these in a NASTRAN finite element analysis to simulate a prostate tumor in the pelvic cavity. The measurements show a wise separation between the elastic modulus of tumors and soft tissues such as muscle and prostate. NASTRAN analyses show the ability to dilineate regions of different elasticity based on the pattern of vibration amplitudes. The ability to change vibration frequency within the 100-300 Hz band seems particularly helpful in simulations and experiments which visualize small stiff inclusions in tissues. Preliminary results suppor the postulate that sonoelasticity imaging can provide useful information concerning tissue properties that are not otherwise obtainable.